2012
Risk Factors for Death in 632 Patients with Sickle Cell Anemia in the United States and United Kingdom
Gladwin M, Barst R, Gibbs J, Hildesheim M, Sachdev V, Nouraie M, Hassell K, Little J, Schraufnagel D, Krishnamurti L, Novelli E, Girgis R, Zhang Y, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Castro O, Taylor J, Goldsmith J, Gordeuk V, Kato G, Machado R. Risk Factors for Death in 632 Patients with Sickle Cell Anemia in the United States and United Kingdom. Blood 2012, 120: 3240. DOI: 10.1182/blood.v120.21.3240.3240.Peer-Reviewed Original ResearchTricuspid regurgitant jet velocityHigher tricuspid regurgitant jet velocityProportional hazards regression analysisHigher NT-proBNPUnadjusted hazard ratioNT-proBNPHazards regression analysisSickle cell diseasePulmonary hypertensionRisk factorsGlaxo Smith KlineAspartate aminotransferaseHazard ratioCell diseaseCox proportional hazards regression analysisMean pulmonary artery pressureSix-minute walk distanceSickle cell disease patientsPopulation screening studiesPulmonary artery pressureRight heart catheterizationRegurgitant jet velocityRisk of deathDoppler echocardiographic measurementsScreening study
2011
Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study
Goel R, Hassell K, Machado R, Barst R, Yovetich N, Kato G, Gordeuk V, Little J, Gibbs J, Schraufnagel D, Girgis R, Rosenzweig E, Morris C, Badesch D, Lanzkron S, Onyekwere O, Nouraie M, Castro O, Sachdev V, Waclawiw M, Woolson R, Goldsmith J, Gladwin M, Krishnamurti L. Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study. Blood 2011, 118: 1074. DOI: 10.1182/blood.v118.21.1074.1074.Peer-Reviewed Original ResearchTR jet velocitySickle cell diseaseSix-minute walk distanceAvascular necrosisMultivariable linear regressionPulmonary hypertensionCell diseasePrimary endpointWalk distanceChronic painSCD patientsSevere genotypeAmerican Thoracic Society guidelinesSix-minute walk testSelf-reported medical historyThoracic Society guidelinesMulti-center studySided p valueGreater predictive valueCardiopulmonary factorsOral sildenafilPain 2NT-proBNPExercise capacityWalk test
2010
Cigarette Smoking Is An Independent Predictor of Chronic Pain In Sickle Cell Patients: Results From the Walk-PHaSST Study
Goel R, Hassell K, Castro O, Barst R, Rosenzweig E, Sachdev V, Machado R, Gibbs S, Little J, Schraufnagel D, Girgis R, Morris C, Badesch D, Lanzkron S, Goldsmith J, Gordeuk V, Kato G, Gladwin M, Krishnamurti L. Cigarette Smoking Is An Independent Predictor of Chronic Pain In Sickle Cell Patients: Results From the Walk-PHaSST Study. Blood 2010, 116: 4804. DOI: 10.1182/blood.v116.21.4804.4804.Peer-Reviewed Original ResearchChronic SCD painSickle cell diseaseTricuspid regurgitant velocitySCD painChronic painPack yearsSmoking historyCigarette smokingCigarette smokersMedical historySCD genotypeSmall single-center studiesSix-minute walk distanceStepwise multivariable logistic regressionMultivariable logistic regression modelEfficacy of sildenafilEnvironmental smoke exposureFormer cigarette smokingMean pack yearsVaso-occlusive painAcute chest syndromeSingle-center studyAbnormal platelet activationMultivariable logistic regressionEffect sizePredictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study
Barst R, Kato G, Sachdev V, Nouraie M, Machado R, Hassell K, Gibbs S, Little J, Schraufnagel D, Krishnamurti L, Girgis R, Morris C, Badesch D, Lanzkron S, Castro O, Rosenzweig E, Goldsmith J, Gladwin M, Gordeuk V. Predictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study. Blood 2010, 116: 947. DOI: 10.1182/blood.v116.21.947.947.Peer-Reviewed Original ResearchHigher tricuspid regurgitation velocityTricuspid regurgitation velocitySickle cell diseaseSickle cell anemiaRight ventricular systolic pressureVentricular filling pressureVentricular systolic pressureCell anemiaCell diseaseEa ratioExercise capacitySystolic pressureFilling pressureFunctional capacityHemolytic componentElevated tricuspid regurgitant jet velocityTricuspid regurgitant jet velocitySix-minute walk distanceSix-minute walk testSickle cell disease patientsDecreased exercise capacityHemoglobin oxygen desaturationBaseline clinical characteristicsImpaired exercise capacitySickle cell anemia patients
2009
Safety and Efficacy of Sildenafil Therapy for Doppler-Defined Pulmonary Hypertension in Patients with Sickle Cell Disease: Preliminary Results of the Walk-PHaSST Clinical Trial.
Machado R, Barst R, Yovetich N, Hassell K, Goldsmith J, Woolson R, Gordeuk V, Gibbs S, Little J, Kato G, Schraufnagel D, Krishnamurti L, Girgis R, Morris C, Berman-Rosenzweig E, Badesch D, Waclawiw M, Gladwin M. Safety and Efficacy of Sildenafil Therapy for Doppler-Defined Pulmonary Hypertension in Patients with Sickle Cell Disease: Preliminary Results of the Walk-PHaSST Clinical Trial. Blood 2009, 114: 571. DOI: 10.1182/blood.v114.22.571.571.Peer-Reviewed Original ResearchSerious adverse eventsSickle cell diseaseRight heart catheterizationBrief Pain InventoryPulmonary hypertensionCell diseaseAdverse eventsArterial pressureMean pulmonary arterial pressureSix-minute walk distanceApparent safety issuesDose of sildenafilSecondary endpoint analysisWeeks of sildenafilPulmonary vascular resistancePulmonary arterial pressureTransthoracic Doppler echocardiographySystemic arterial pressurePremature study terminationSingle test doseSignificant differencesSignificant increaseSickle cell anemiaOral sildenafilSildenafil dosing