Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath
Chiang K, Rizk J, Nelson D, Krishnamurti L, Subbian S, Imig J, Khan I, Reddy S, Gupta A. Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath. Expert Opinion On Therapeutic Targets 2022, 26: 13-28. PMID: 35068281, PMCID: PMC10119876, DOI: 10.1080/14728222.2022.2031975.Peer-Reviewed Original ResearchConceptsCOVID-19 pneumoniaDP2 receptorLong-haul COVID-19COVID-19Dual receptor antagonistProgressive lung injuryRapid symptomatic reliefRole of TXAAcute respiratory distressMaladaptive immune responsesThromboxane prostanoid (TP) receptorFatty acid levelsLung injuryRespiratory distressSymptomatic reliefDual antagonismRespiratory dysfunctionImmunomodulatory agentsRapid reliefReceptor antagonistAntifibrotic agentsCyclooxygenase metabolitesImmune responseProstanoid receptorsSystemic circulation