Diet-Induced Obesity Accelerates Acute Lymphoblastic Leukemia Progression in Two Murine Models
Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD. Diet-Induced Obesity Accelerates Acute Lymphoblastic Leukemia Progression in Two Murine Models. Cancer Prevention Research 2010, 3: 1259-1264. PMID: 20823291, PMCID: PMC2955776, DOI: 10.1158/1940-6207.capr-10-0087.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaAKR miceLeukemia incidenceAKR/J miceOld obese miceSimilar median survivalEffect of obesityInterleukin-6 levelsObesity-related hormonesAcute lymphoblastic leukemia progressionDiet-Induced ObesityHigh-fat dietMedian survivalObese miceSpleen weightLymphoblastic leukemiaWBC countJ miceMurine modelObesityAnimal modelsLeukemia progressionLeukemia pathogenesisMiceObserved associations