A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
Kabeche L, Nguyen HD, Buisson R, Zou L. A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation. Science 2017, 359: 108-114. PMID: 29170278, PMCID: PMC5875943, DOI: 10.1126/science.aan6490.Peer-Reviewed Original ResearchConceptsFaithful chromosome segregationChromosome segregationR-loopsATR pathwayCyclin-dependent kinase 1 (CDK1) activityWhole chromosome missegregationReplication stress responseReplication protein ADNA damage responseCentromere protein FKinase 1 activityATR functionAurora BDamage responseChromosome instabilityCentromeresProtein FAtaxia telangiectasiaAurora AUnexpected roleStress responseDNA damageDNA synthesisATRProtein AMitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities
Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H. Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities. Trends In Cancer 2017, 3: 225-234. PMID: 28718433, PMCID: PMC5518619, DOI: 10.1016/j.trecan.2017.02.001.Peer-Reviewed Original ResearchConceptsDNA double-strand breaksDNA damage responseSegregation errorsMitotic DNA damage responseNovel anticancer therapeutic strategyMitotic DNA damageChromosome segregation errorsDouble-strand breaksNumerical chromosomal instabilityGenomic integrityDamage responseChromosome instabilityAnticancer therapeutic strategiesChromosomal instabilityGenomic damageDNA damageCancer cellsNormal cellsMitosisCellsUnstable tumorsActivation inducesTherapeutic strategiesPathwayThorough understanding