2015
Shugoshin-1 Balances Aurora B Kinase Activity via PP2A to Promote Chromosome Bi-orientation
Meppelink A, Kabeche L, Vromans MJ, Compton DA, Lens SM. Shugoshin-1 Balances Aurora B Kinase Activity via PP2A to Promote Chromosome Bi-orientation. Cell Reports 2015, 11: 508-515. PMID: 25892238, PMCID: PMC4718550, DOI: 10.1016/j.celrep.2015.03.052.Peer-Reviewed Original Research
2014
DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation
Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA. DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation. Cancer Discovery 2014, 4: 1281-1289. PMID: 25107667, PMCID: PMC4221427, DOI: 10.1158/2159-8290.cd-14-0403.Peer-Reviewed Original ResearchConceptsDNA damage responseNumerical chromosomal instabilityDNA damageChromosome segregationChromosomal instabilityWhole chromosomal instabilityChromosome segregation defectsDefective chromosome segregationWhole chromosome missegregationChromosome segregation errorsPersistent DNA damageS-CINW-CINSegregation defectsMicrotubule attachmentDDR proteinsEntire chromosomesPlk1 kinaseCell divisionSegregation errorsMitotic processesChromosomesMitosisStructural rearrangementsCancer cellsSTAG2 promotes error correction in mitosis by regulating kinetochore–microtubule attachments
Kleyman M, Kabeche L, Compton DA. STAG2 promotes error correction in mitosis by regulating kinetochore–microtubule attachments. Journal Of Cell Science 2014, 127: 4225-4233. PMID: 25074805, PMCID: PMC4179491, DOI: 10.1242/jcs.151613.Peer-Reviewed Original Research
2012
Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments. Journal Of Cell Biology 2012, 199: 285-301. PMID: 23045552, PMCID: PMC3471233, DOI: 10.1083/jcb.201203091.Peer-Reviewed Original ResearchConceptsSpindle assembly checkpointKT-MT attachmentsChromosome alignmentAccurate chromosome segregationC-terminal phosphorylationKinetochore-microtubule attachmentsUnderlying regulatory mechanismsPlk1 recruitmentMitosis reliesChromosome segregationChromosome movementMT attachmentPlk1 kinaseSpindle bipolarityMicrotubule interfaceMT dynamicsRegulatory mechanismsCLASP2Plk1CDK1PhosphorylationAttachment stabilityKinetochoresMitosisKinaseCheckpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells
Kabeche L, Compton DA. Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells. Current Biology 2012, 22: 638-644. PMID: 22405866, PMCID: PMC3326208, DOI: 10.1016/j.cub.2012.02.030.Peer-Reviewed Original ResearchAurora Kinase BAurora KinasesCalcium-Binding ProteinsCdc20 ProteinsCell Cycle ProteinsCell LineCentromereChromosome SegregationGreen Fluorescent ProteinsKinetochoresM Phase Cell Cycle CheckpointsMad2 ProteinsMicroscopy, FluorescenceMicrotubulesNuclear ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSpindle ApparatusTransfectionTubulin