2014
DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation
Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA. DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation. Cancer Discovery 2014, 4: 1281-1289. PMID: 25107667, PMCID: PMC4221427, DOI: 10.1158/2159-8290.cd-14-0403.Peer-Reviewed Original ResearchConceptsDNA damage responseNumerical chromosomal instabilityDNA damageChromosome segregationChromosomal instabilityWhole chromosomal instabilityChromosome segregation defectsDefective chromosome segregationWhole chromosome missegregationChromosome segregation errorsPersistent DNA damageS-CINW-CINSegregation defectsMicrotubule attachmentDDR proteinsEntire chromosomesPlk1 kinaseCell divisionSegregation errorsMitotic processesChromosomesMitosisStructural rearrangementsCancer cells
2013
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation
Kabeche L, Compton DA. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature 2013, 502: 110-113. PMID: 24013174, PMCID: PMC3791168, DOI: 10.1038/nature12507.Peer-Reviewed Original Research
2012
Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells
Kabeche L, Compton DA. Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells. Current Biology 2012, 22: 638-644. PMID: 22405866, PMCID: PMC3326208, DOI: 10.1016/j.cub.2012.02.030.Peer-Reviewed Original ResearchAurora Kinase BAurora KinasesCalcium-Binding ProteinsCdc20 ProteinsCell Cycle ProteinsCell LineCentromereChromosome SegregationGreen Fluorescent ProteinsKinetochoresM Phase Cell Cycle CheckpointsMad2 ProteinsMicroscopy, FluorescenceMicrotubulesNuclear ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSpindle ApparatusTransfectionTubulin