Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments. Journal Of Cell Biology 2012, 199: 285-301. PMID: 23045552, PMCID: PMC3471233, DOI: 10.1083/jcb.201203091.Peer-Reviewed Original ResearchConceptsSpindle assembly checkpointKT-MT attachmentsChromosome alignmentAccurate chromosome segregationC-terminal phosphorylationKinetochore-microtubule attachmentsUnderlying regulatory mechanismsPlk1 recruitmentMitosis reliesChromosome segregationChromosome movementMT attachmentPlk1 kinaseSpindle bipolarityMicrotubule interfaceMT dynamicsRegulatory mechanismsCLASP2Plk1CDK1PhosphorylationAttachment stabilityKinetochoresMitosisKinaseCheckpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells
Kabeche L, Compton DA. Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells. Current Biology 2012, 22: 638-644. PMID: 22405866, PMCID: PMC3326208, DOI: 10.1016/j.cub.2012.02.030.Peer-Reviewed Original ResearchAurora Kinase BAurora KinasesCalcium-Binding ProteinsCdc20 ProteinsCell Cycle ProteinsCell LineCentromereChromosome SegregationGreen Fluorescent ProteinsKinetochoresM Phase Cell Cycle CheckpointsMad2 ProteinsMicroscopy, FluorescenceMicrotubulesNuclear ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSpindle ApparatusTransfectionTubulin