2022
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
Black E, Joo Y, Kabeche L. Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma. Biochemical Journal 2022, 479: 2345-2349. PMID: 36416754, PMCID: PMC9704517, DOI: 10.1042/bcj20220461.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCheckpoint Kinase 1FemaleLymphomaMiceNeoplasm Recurrence, LocalPhosphatidylinositol 3-KinasesProtein Kinase InhibitorsProtein KinasesConceptsReplication stressChk1 activityDNA damage response pathwayChk1 inhibitorsDNA replication stressInhibitor resistanceDamage response pathwayGenome instabilityPI3K/AktResponse pathwaysMolecular mechanismsNovel roleChk1Cancer therapyCancer developmentFemale fertilityDevelopment of resistancePathwayLethal levelsMultiple mechanismsAlternative pathwayNF-κBDrug resistanceIntriguing targetDisease states
2017
A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
Kabeche L, Nguyen HD, Buisson R, Zou L. A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation. Science 2017, 359: 108-114. PMID: 29170278, PMCID: PMC5875943, DOI: 10.1126/science.aan6490.Peer-Reviewed Original ResearchConceptsFaithful chromosome segregationChromosome segregationR-loopsATR pathwayCyclin-dependent kinase 1 (CDK1) activityWhole chromosome missegregationReplication stress responseReplication protein ADNA damage responseCentromere protein FKinase 1 activityATR functionAurora BDamage responseChromosome instabilityCentromeresProtein FAtaxia telangiectasiaAurora AUnexpected roleStress responseDNA damageDNA synthesisATRProtein A