2014
Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis
Godek KM, Kabeche L, Compton DA. Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis. Nature Reviews Molecular Cell Biology 2014, 16: 57-64. PMID: 25466864, PMCID: PMC4568440, DOI: 10.1038/nrm3916.Peer-Reviewed Original ResearchSTAG2 promotes error correction in mitosis by regulating kinetochore–microtubule attachments
Kleyman M, Kabeche L, Compton DA. STAG2 promotes error correction in mitosis by regulating kinetochore–microtubule attachments. Journal Of Cell Science 2014, 127: 4225-4233. PMID: 25074805, PMCID: PMC4179491, DOI: 10.1242/jcs.151613.Peer-Reviewed Original Research
2013
Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation
Kabeche L, Compton DA. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature 2013, 502: 110-113. PMID: 24013174, PMCID: PMC3791168, DOI: 10.1038/nature12507.Peer-Reviewed Original Research
2012
Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments
Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments. Journal Of Cell Biology 2012, 199: 285-301. PMID: 23045552, PMCID: PMC3471233, DOI: 10.1083/jcb.201203091.Peer-Reviewed Original ResearchConceptsSpindle assembly checkpointKT-MT attachmentsChromosome alignmentAccurate chromosome segregationC-terminal phosphorylationKinetochore-microtubule attachmentsUnderlying regulatory mechanismsPlk1 recruitmentMitosis reliesChromosome segregationChromosome movementMT attachmentPlk1 kinaseSpindle bipolarityMicrotubule interfaceMT dynamicsRegulatory mechanismsCLASP2Plk1CDK1PhosphorylationAttachment stabilityKinetochoresMitosisKinaseCheckpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells
Kabeche L, Compton DA. Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells. Current Biology 2012, 22: 638-644. PMID: 22405866, PMCID: PMC3326208, DOI: 10.1016/j.cub.2012.02.030.Peer-Reviewed Original ResearchAurora Kinase BAurora KinasesCalcium-Binding ProteinsCdc20 ProteinsCell Cycle ProteinsCell LineCentromereChromosome SegregationGreen Fluorescent ProteinsKinetochoresM Phase Cell Cycle CheckpointsMad2 ProteinsMicroscopy, FluorescenceMicrotubulesNuclear ProteinsProtein Serine-Threonine KinasesRepressor ProteinsSpindle ApparatusTransfectionTubulin