2020
Interplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival
Shan N, Li N, Dai Q, Hou L, Yan X, Amei A, Lu L, Wang Z. Interplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival. Cancers 2020, 12: 2230. PMID: 32785169, PMCID: PMC7466003, DOI: 10.3390/cancers12082230.Peer-Reviewed Original ResearchT cell activationBreast cancer patient survivalCancer patient survivalOverall survivalCell activationBreast cancerExpression of tRFsImproved survivalPatient survivalMultivariate Cox regression modelBreast cancer patientsCox regression modelKaplan-Meier survivalSpearman correlation analysisEffector CD8Cytotoxic functionCancer patientsExhaustion groupsTherapeutic targetCancer progressionCancerSurvivalGene co-expression network analysisActivation groupTRNA-derived fragments
2019
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma
Lu L, Gaffney SG, Cannataro VL, Townsend J. Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma. Oral Oncology 2019, 101: 104554. PMID: 31887619, PMCID: PMC7273869, DOI: 10.1016/j.oraloncology.2019.104554.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLymphocyte ActivationMaleMethyltransferasesMiddle AgedNeoplasm GradingNeoplasm StagingPrognosisProportional Hazards ModelsSquamous Cell Carcinoma of Head and NeckT-LymphocytesYoung AdultConceptsT cell activation scoreT cell activation statusAdjusted hazard ratioPatient survivalHPV statusHazard ratioActivation statusActivation scoresKaplan-Meier survival curvesImmune checkpoint blockadeCox regression modelNeck squamous carcinomaPotential therapeutic targetT cell activationHNSCC patientsSquamous carcinomaPatient mortalityLonger survivalExhaustion groupsTherapeutic targetSurvival curvesSignificant associationMRNA expressionPatientsSurvival