2019
Nerve Growth Factor Improves the Outcome of Type 2 Diabetes—Induced Hypotestosteronemia and Erectile Dysfunction
Wu Y, Yang C, Meng F, Que F, Xiao W, Rao H, Wan Y, Taylor HS, Lu L. Nerve Growth Factor Improves the Outcome of Type 2 Diabetes—Induced Hypotestosteronemia and Erectile Dysfunction. Reproductive Sciences 2019, 26: 386-393. PMID: 29724155, DOI: 10.1177/1933719118773421.Peer-Reviewed Original ResearchConceptsNerve growth factorErectile dysfunctionTotal testosteroneFree testosteroneDiabetes-induced erectile dysfunctionNGF treatmentGrowth factorHyperglycemia-induced downregulationErectile Function scoreIIEF-5 scoreSerum total testosteroneType 2 diabetesMouse Leydig cellsSteroidogenic acute regulatory proteinDiabetic malesSensorimotor polyneuropathySerum testosteroneFunction scoresAcute regulatory proteinInternational IndexClinical studiesED outcomesCytochrome P450 11A1Testosterone biosynthesisLeydig cells
2018
Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats
Gao HT, Xu R, Cao WX, Di QN, Li RX, Lu L, Xu Q, Yu SQ. Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology And Applied Pharmacology 2018, 341: 87-97. PMID: 29366639, DOI: 10.1016/j.taap.2018.01.013.Peer-Reviewed Original ResearchConceptsRat reproductive systemFood emulsifier glycerin monostearateReproductive systemMale rat reproductive systemSteroidogenic proteinsMale reproductive toxicityMale reproductive systemTime-dependent mannerSerum testosteroneAndrogen metabolismMale ratsReproductive toxicityMorphological damageUbiquitous phthalate estersMetabonomic analysisDaily dietSimultaneous exposureToxic effectsRatsGlycerin monostearateMixPToxicityHormone biosynthesisExposureGavage