2020
Zinc supplement ameliorates phthalates-induced reproductive toxicity in male rats
Gao HT, Di QN, Qian LL, Lu L, Li RX, Cao WX, Xu Q. Zinc supplement ameliorates phthalates-induced reproductive toxicity in male rats. Chemosphere 2020, 246: 125828. PMID: 31927381, DOI: 10.1016/j.chemosphere.2020.125828.Peer-Reviewed Original ResearchConceptsZinc supplementsMale ratsReproductive toxicityReproductive functionProtein expressionSteroidogenic proteinsSub-chronic exposureMale reproductive functionMale reproductive toxicityPathological examinationRat testicular cellsRatsTesticular cellsLHHealth risksExposureSerumSupplementsUrineToxicityMixture exposureTestisAlterationsExpressionToxicity evaluation
2019
Nerve Growth Factor Improves the Outcome of Type 2 Diabetes—Induced Hypotestosteronemia and Erectile Dysfunction
Wu Y, Yang C, Meng F, Que F, Xiao W, Rao H, Wan Y, Taylor HS, Lu L. Nerve Growth Factor Improves the Outcome of Type 2 Diabetes—Induced Hypotestosteronemia and Erectile Dysfunction. Reproductive Sciences 2019, 26: 386-393. PMID: 29724155, DOI: 10.1177/1933719118773421.Peer-Reviewed Original ResearchConceptsNerve growth factorErectile dysfunctionTotal testosteroneFree testosteroneDiabetes-induced erectile dysfunctionNGF treatmentGrowth factorHyperglycemia-induced downregulationErectile Function scoreIIEF-5 scoreSerum total testosteroneType 2 diabetesMouse Leydig cellsSteroidogenic acute regulatory proteinDiabetic malesSensorimotor polyneuropathySerum testosteroneFunction scoresAcute regulatory proteinInternational IndexClinical studiesED outcomesCytochrome P450 11A1Testosterone biosynthesisLeydig cells
2018
Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats
Gao HT, Xu R, Cao WX, Di QN, Li RX, Lu L, Xu Q, Yu SQ. Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology And Applied Pharmacology 2018, 341: 87-97. PMID: 29366639, DOI: 10.1016/j.taap.2018.01.013.Peer-Reviewed Original ResearchConceptsRat reproductive systemFood emulsifier glycerin monostearateReproductive systemMale rat reproductive systemSteroidogenic proteinsMale reproductive toxicityMale reproductive systemTime-dependent mannerSerum testosteroneAndrogen metabolismMale ratsReproductive toxicityMorphological damageUbiquitous phthalate estersMetabonomic analysisDaily dietSimultaneous exposureToxic effectsRatsGlycerin monostearateMixPToxicityHormone biosynthesisExposureGavage
2017
Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats
Gao HT, Xu R, Cao WX, Qian LL, Wang M, Lu L, Xu Q, Yu SQ. Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food And Chemical Toxicology 2017, 101: 94-104. PMID: 28089693, DOI: 10.1016/j.fct.2017.01.011.Peer-Reviewed Original ResearchConceptsLong-term low-dose exposureMale reproductive toxicityLow-dose exposureReproductive toxicityMale rat reproductive systemSteroidogenic proteinsRat reproductive systemApoptosis-related proteinsPathological examinationRat testicular cellsMale ratsTesticular testosteroneCell cycle progressionRatsTesticular cellsReproductive systemTestosteroneToxicityExposureCycle progressionCell cycleIntegrated exposureButyl benzylToxicity evaluationMixP
2016
Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats
Gao HT, Xu R, Cao WX, Zhou X, Yan YH, Lu L, Xu Q, Shen Y. Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats. PLOS ONE 2016, 11: e0161253. PMID: 27575856, PMCID: PMC5004918, DOI: 10.1371/journal.pone.0161253.Peer-Reviewed Original ResearchConceptsInternal exposure levelsReproductive toxicityExposure levelsMale ratsTestosterone levelsFood emulsifier glycerin monostearatePAE exposureHistopathology of testesMale reproductive toxicityDEHP groupRat urineUbiquitous phthalate estersRatsPhthalate monoestersHistopathologyInjuryToxicityTestisGlycerin monostearatePrimary metabolitesExposureUPLC-MSFood additivesGavageLevels