2017
Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats
Gao HT, Xu R, Cao WX, Qian LL, Wang M, Lu L, Xu Q, Yu SQ. Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats. Food And Chemical Toxicology 2017, 101: 94-104. PMID: 28089693, DOI: 10.1016/j.fct.2017.01.011.Peer-Reviewed Original ResearchConceptsLong-term low-dose exposureMale reproductive toxicityLow-dose exposureReproductive toxicityMale rat reproductive systemSteroidogenic proteinsRat reproductive systemApoptosis-related proteinsPathological examinationRat testicular cellsMale ratsTesticular testosteroneCell cycle progressionRatsTesticular cellsReproductive systemTestosteroneToxicityExposureCycle progressionCell cycleIntegrated exposureButyl benzylToxicity evaluationMixP
2016
Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats
Gao HT, Xu R, Cao WX, Zhou X, Yan YH, Lu L, Xu Q, Shen Y. Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats. PLOS ONE 2016, 11: e0161253. PMID: 27575856, PMCID: PMC5004918, DOI: 10.1371/journal.pone.0161253.Peer-Reviewed Original ResearchConceptsInternal exposure levelsReproductive toxicityExposure levelsMale ratsTestosterone levelsFood emulsifier glycerin monostearatePAE exposureHistopathology of testesMale reproductive toxicityDEHP groupRat urineUbiquitous phthalate estersRatsPhthalate monoestersHistopathologyInjuryToxicityTestisGlycerin monostearatePrimary metabolitesExposureUPLC-MSFood additivesGavageLevels