2021
The effect of varenicline on smoking and drinking outcomes among Black and White adults with alcohol use disorder and co-occurring cigarette smoking: A secondary analysis of two clinical trials
Haeny AM, Gueorguieva R, Montgomery L, Bold KW, Fucito LM, Wu R, Muvvala SB, Zweben A, O'Malley SS. The effect of varenicline on smoking and drinking outcomes among Black and White adults with alcohol use disorder and co-occurring cigarette smoking: A secondary analysis of two clinical trials. Addictive Behaviors 2021, 122: 106970. PMID: 34216871, PMCID: PMC9426655, DOI: 10.1016/j.addbeh.2021.106970.Peer-Reviewed Original ResearchConceptsEffects of vareniclineAlcohol use disorderCigarette smokingClinical trialsUse disordersWhite adultsEfficacy of vareniclineNumber of drinksVareniclineSmokingPrimary analysisAlcohol treatmentSecondary analysisAlcohol useTrialsBlack participantsDrinking outcomesLinear mixed modelsAdultsWhite peopleWhite participantsMixed modelingCigarettesDisordersTreatment
2020
An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study.
Fucito LM, Wu R, O'Malley SS, Hanrahan TH, Ikomi JT, Muvvala S, Carroll KM, Gueorguieva R. An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study. The Journal Of Smoking Cessation 2020, 15: 119-127. PMID: 33312238, PMCID: PMC7731353, DOI: 10.1017/jsc.2020.13.Peer-Reviewed Original ResearchFeasibility/acceptabilityHeavy drinking smokersAlcohol counsellingHeavy drinkingBehavioral interventionsPilot studyOpen-label vareniclineRandomized pilot studySignificant health burdenComputer-generated tableTobacco pharmacotherapyHealth burdenQuit ratesPilot trialResearch clinicDrinking reductionsVareniclineBehavioural counsellingAlcohol treatmentCombined smokingMedium effect sizeSmokingSmokersCounsellingDrinking
2019
Longitudinal Findings from a Randomized Clinical Trial of Varenicline for Alcohol Use Disorder with Comorbid Cigarette Smoking
Bold KW, Zweben A, Fucito LM, Piepmeier ME, Muvvala S, Wu R, Gueorguieva R, O'Malley SS. Longitudinal Findings from a Randomized Clinical Trial of Varenicline for Alcohol Use Disorder with Comorbid Cigarette Smoking. Alcohol Clinical And Experimental Research 2019, 43: 937-944. PMID: 30817018, PMCID: PMC7039307, DOI: 10.1111/acer.13994.Peer-Reviewed Original ResearchConceptsEnd of treatmentAlcohol use disorderHeavy drinking daysMedical managementCigarette smokingComorbid cigarette smokingUse disordersDrinking daysCo-occurring alcohol use disorderHigh ratePlacebo-controlled trialBetter clinical outcomesAssessment of alcoholPercent of participantsVarenicline treatmentClinical outcomesSmoking abstinenceParallel groupClinical trialsTimeline FollowVareniclineSmoking behaviorAlcohol treatmentPosttreatment outcomesMultisite trial
2018
Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial
O’Malley S, Zweben A, Fucito LM, Wu R, Piepmeier ME, Ockert DM, Bold KW, Petrakis I, Muvvala S, Jatlow P, Gueorguieva R. Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial. JAMA Psychiatry 2018, 75: 129-138. PMID: 29261824, PMCID: PMC5838706, DOI: 10.1001/jamapsychiatry.2017.3544.Peer-Reviewed Original ResearchConceptsAlcohol use disorderMedical managementUse disordersCigarette smokingWeek 9Varenicline tartrateEfficacy of vareniclinePlacebo-controlled trialBehavioral health risksComorbid cigarette smokingRace/ethnicityAlcohol dependence criteriaSmoking 2Medication adherenceOutpatient clinicPlacebo pillsMean ageEligible participantsSmoking abstinenceClinical trialsParallel groupPlaceboMAIN OUTCOMEVareniclineWeek 13
2014
“Killing Two Birds with One Stone”: Alcohol Use Reduction Interventions with Potential Efficacy at Enhancing Self-control
Leeman RF, Bogart D, Fucito LM, Boettiger CA. “Killing Two Birds with One Stone”: Alcohol Use Reduction Interventions with Potential Efficacy at Enhancing Self-control. Current Addiction Reports 2014, 1: 41-52. PMID: 24914414, PMCID: PMC4048018, DOI: 10.1007/s40429-013-0008-1.Peer-Reviewed Original ResearchAlcohol useCognitive bias modificationNicotinic partial agonist vareniclineBias modificationPartial agonist vareniclineNeurophysiological interventionBehavioral interventionsEmpirical supportAgonist vareniclineFuture researchReduction interventionsPurported mechanismsInterventionEmpirical evidenceStrong evidenceFurther researchPotential efficacyResearchSuggestive evidenceMultiple interventionsDual efficacyEvidenceDrinkingGood evidenceVarenicline
2011
A preliminary investigation of varenicline for heavy drinking smokers
Fucito LM, Toll BA, Wu R, Romano DM, Tek E, O’Malley S. A preliminary investigation of varenicline for heavy drinking smokers. Psychopharmacology 2011, 215: 655-663. PMID: 21221531, PMCID: PMC3645986, DOI: 10.1007/s00213-010-2160-9.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersActive medicationPretreatment groupAlcohol cravingHeavy drinkersOpen-label phaseSmoking cessation pharmacotherapyEffects of vareniclineHeavy drinking daysGreater reductionPlacebo leadVarenicline pretreatmentCessation counselingCessation pharmacotherapyAbstinence ratesCigarette smokingVareniclineSmoking changesDrinking daysPotential treatmentSmokingAlcohol dependenceEntire study periodSmokersHeavy drinking