2021
The effect of varenicline on smoking and drinking outcomes among Black and White adults with alcohol use disorder and co-occurring cigarette smoking: A secondary analysis of two clinical trials
Haeny AM, Gueorguieva R, Montgomery L, Bold KW, Fucito LM, Wu R, Muvvala SB, Zweben A, O'Malley SS. The effect of varenicline on smoking and drinking outcomes among Black and White adults with alcohol use disorder and co-occurring cigarette smoking: A secondary analysis of two clinical trials. Addictive Behaviors 2021, 122: 106970. PMID: 34216871, PMCID: PMC9426655, DOI: 10.1016/j.addbeh.2021.106970.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCigarette SmokingDouble-Blind MethodFemaleHumansMaleSmokingSmoking CessationTreatment OutcomeVareniclineConceptsEffects of vareniclineAlcohol use disorderCigarette smokingClinical trialsUse disordersWhite adultsEfficacy of vareniclineNumber of drinksVareniclineSmokingPrimary analysisAlcohol treatmentSecondary analysisAlcohol useTrialsBlack participantsDrinking outcomesLinear mixed modelsAdultsWhite peopleWhite participantsMixed modelingCigarettesDisordersTreatment
2018
Drinking Goals and Attainment in a Naltrexone Trial of Young Adult Heavy Drinkers
DeMartini KS, Foster DW, Corbin WR, Fucito LM, Romano D, Leeman RF, Kranzler HR, O’Malley S. Drinking Goals and Attainment in a Naltrexone Trial of Young Adult Heavy Drinkers. Journal Of Consulting And Clinical Psychology 2018, 86: 765-774. PMID: 30138015, PMCID: PMC6435339, DOI: 10.1037/ccp0000323.Peer-Reviewed Original ResearchConceptsTreatment outcomesAdult heavy drinkersYoung adult heavy drinkersHeavy drinkersDrinking goalEnd of treatmentPeak drinkingBetter treatment outcomesAlcohol use disorderImpact treatment outcomesTypical drinkingYoung adult drinkersEfficacy trialsUse disordersBrief counselingGoal settingIntervention effectsGoal-setting exercisesAdult drinkersDrinkersOutcomesDrinkingTreatmentImportant targetMidtreatmentEffect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial
O’Malley S, Zweben A, Fucito LM, Wu R, Piepmeier ME, Ockert DM, Bold KW, Petrakis I, Muvvala S, Jatlow P, Gueorguieva R. Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial. JAMA Psychiatry 2018, 75: 129-138. PMID: 29261824, PMCID: PMC5838706, DOI: 10.1001/jamapsychiatry.2017.3544.Peer-Reviewed Original ResearchConceptsAlcohol use disorderMedical managementUse disordersCigarette smokingWeek 9Varenicline tartrateEfficacy of vareniclinePlacebo-controlled trialBehavioral health risksComorbid cigarette smokingRace/ethnicityAlcohol dependence criteriaSmoking 2Medication adherenceOutpatient clinicPlacebo pillsMean ageEligible participantsSmoking abstinenceClinical trialsParallel groupPlaceboMAIN OUTCOMEVareniclineWeek 13
2017
Using Sleep Interventions to Engage and Treat Heavy‐Drinking College Students: A Randomized Pilot Study
Fucito LM, DeMartini KS, Hanrahan TH, Yaggi HK, Heffern C, Redeker NS. Using Sleep Interventions to Engage and Treat Heavy‐Drinking College Students: A Randomized Pilot Study. Alcohol Clinical And Experimental Research 2017, 41: 798-809. PMID: 28118486, PMCID: PMC5378596, DOI: 10.1111/acer.13342.Peer-Reviewed Original ResearchConceptsHeavy-drinking college studentsAlcohol-related consequencesCollege studentsSleep interventionsGreater sleep improvementsBehavioral sleep interventionsHeavy drinking college studentsTreatment engagement strategiesHeavy-drinking studentsHigher alcohol consumption levelsSubsequent drinking outcomesWeb-based interventionSleep concernsEffective alcohol interventionsSleep treatmentsDrinking outcomesDrinking weekAlcohol interventionsSleep improvementImproved sleep qualitySleep contentControl conditionAlcohol consumption levelsAlcohol useRecruitment ads
2015
Predictors of Abstinence From Heavy Drinking During Follow-Up in COMBINE.
Gueorguieva R, Wu R, Fucito LM, O'Malley SS. Predictors of Abstinence From Heavy Drinking During Follow-Up in COMBINE. Journal Of Studies On Alcohol And Drugs 2015, 76: 935-41. PMID: 26562602, PMCID: PMC4712662, DOI: 10.15288/jsad.2015.76.935.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAlcoholismBehavior TherapyFemaleFollow-Up StudiesHumansLogistic ModelsMaleTreatment OutcomeConceptsLong-term outcomesBetter long-term outcomesBetter clinical outcomesDrinking outcomesHeavy drinking daysLogistic regression analysisStrongest predictorLogistic regression modelsPredictors of abstinenceFair classification accuracyPatient characteristicsClinical outcomesTerm outcomesCombined PharmacotherapiesClinical trialsBaseline predictorsTreatment outcomesTreatment phaseOptimizing outcomesDrinking daysBetter outcomesAlcohol Dependence (COMBINE) StudyBehavioral interventionsHeavy drinkingAlternative interventionsHow Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal
Hillmer AT, Mason GF, Fucito LM, O'Malley SS, Cosgrove KP. How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal. Alcohol Clinical And Experimental Research 2015, 39: 2268-2282. PMID: 26510169, PMCID: PMC4712074, DOI: 10.1111/acer.12893.Peer-Reviewed Original ResearchConceptsAlcohol dependenceΓ-aminobutyric acidClinical treatmentMajor public health issuePublic health issuePositron emission tomographyRelapse prevention strategiesSingle photon emissionSpecific imaging modalityAlcohol withdrawalTobacco smokingGABA systemNeurotransmitter systemsNeurochemical basisPrevention strategiesDopaminergic functioningEmission tomographyHealth issuesImaging modalitiesWithdrawalSex differencesImaging literatureDopamineTomographyGlutamateAn analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate
Gueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.Peer-Reviewed Original ResearchConceptsAcamprosate effectHeavy drinkingShort abstinenceEnhanced treatment responseMonths of treatmentSubgroup of patientsBody mass indexDrug plasma levelsIdentification of subgroupsBetter prognosisLower BMIMass indexPlasma levelsGlutamatergic hyperactivityTreatment responseAcamprosateCOMBINE StudyPrior treatmentLarger studyConsecutive daysAbstinencePretreatment abstinenceTreatment effectsCognitive inefficiencySubgroupsA Randomized Trial for Hazardous Drinking and Smoking Cessation for Callers to a Quitline
Toll BA, Martino S, O’Malley S, Fucito LM, McKee SA, Kahler CW, Rojewski AM, Mahoney MC, Wu R, Celestino P, Seshadri S, Koutsky J, Hyland A, Cummings KM. A Randomized Trial for Hazardous Drinking and Smoking Cessation for Callers to a Quitline. Journal Of Consulting And Clinical Psychology 2015, 83: 445-454. PMID: 25419583, PMCID: PMC5996380, DOI: 10.1037/a0038183.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCounselingFemaleHotlinesHumansMaleMiddle AgedNew YorkSmokingSmoking CessationTobacco Use DisorderTreatment OutcomeConceptsStandard careHazardous drinkingHigher smoking cessation ratesNew York State Smokers' QuitlineHeavy drinkingBrief motivational counselingSmoking cessation ratesState Smokers' QuitlineBrief alcohol interventionTelephone coachesCessation counselingTreat analysisCessation ratesRandomized trialsTelephone quitlinesCessation successSmoking cessationAcceptable adherenceMotivational counselingQuitlineAlcohol interventionsAlcohol useCareSmokersDrinking
2014
Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT
Gueorguieva R, Wu R, O'Connor PG, Weisner C, Fucito LM, Hoffmann S, Mann K, O'Malley SS. Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT. Alcohol Clinical And Experimental Research 2014, 38: 2647-2656. PMID: 25346505, PMCID: PMC4397985, DOI: 10.1111/acer.12541.Peer-Reviewed Original ResearchAcamprosateAge FactorsAlcohol AbstinenceAlcohol DeterrentsAlcohol DrinkingBehavior TherapyCombined Modality TherapyControlled Clinical Trials as TopicDecision TreesGamma-GlutamyltransferaseGermanyGoalsHumansLogistic ModelsMiddle AgedNaltrexonePredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsTaurineTime FactorsTreatment OutcomeUnited StatesIn With the Old and Out With the New? A Comparison of the Old and New Binge Drinking Standards
Corbin WR, Zalewski S, Leeman RF, Toll BA, Fucito LM, O'Malley SS. In With the Old and Out With the New? A Comparison of the Old and New Binge Drinking Standards. Alcohol Clinical And Experimental Research 2014, 38: 2657-2663. PMID: 25346506, PMCID: PMC9328028, DOI: 10.1111/acer.12514.Peer-Reviewed Original ResearchConceptsIndex of intoxicationRandomized clinical trialsHeavy-drinking young adultsClinical trialsAlcohol abuseDrinking consequencesNegative drinking consequencesYoung adultsNational InstituteDrinking occasionsRiskConsistent evidenceIntoxicationRegression modelsTask ForceAdultsBrief measureDrinking sampleFurther effortsNegative consequencesBingeTrials
2012
Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence
Fucito LM, Park A, Gulliver SB, Mattson ME, Gueorguieva RV, O'Malley SS. Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence. Biological Psychiatry 2012, 72: 832-838. PMID: 22541040, PMCID: PMC3410039, DOI: 10.1016/j.biopsych.2012.03.023.Peer-Reviewed Original ResearchConceptsCigarette smokingAlcohol dependenceBehavioral interventionsAlcohol-dependent smokersCombination of medicationsBaseline demographic differencesPoor treatment outcomesPoor treatment responseDrinking outcomesBetter drinking outcomesSevere alcohol dependenceAlcohol-dependent individualsCigarette intakeAlcohol use outcomesMedical managementPharmacological treatmentTreatment outcomesTreatment responseSmokingSmokersCOMBINE StudyAlcoholism typologyDrinking-related variablesTreatment assignmentNonsmokers
2011
Effect of Night Smoking, Sleep Disturbance, and Their Co-Occurrence on Smoking Outcomes
Peters EN, Fucito LM, Novosad C, Toll BA, O'Malley SS. Effect of Night Smoking, Sleep Disturbance, and Their Co-Occurrence on Smoking Outcomes. Psychology Of Addictive Behaviors 2011, 25: 312-319. PMID: 21443301, PMCID: PMC3571661, DOI: 10.1037/a0023128.Peer-Reviewed Original ResearchConceptsSelf-reported sleep disturbanceCessation failureNight smokingSleep disturbancesSleep habitsGreater sleep disturbanceSmoking cessation treatmentSignificant sleep disturbanceSmoking outcomesPittsburgh Sleep Quality IndexCessation outcomesSleep Quality IndexRisk factorsCessation treatmentNicotine dependenceSingle itemHigh-risk groupPhysiological dependenceNicotine patchSleep cycleSmoking statusSmokersSmokingWeek 1Greater riskA preliminary investigation of varenicline for heavy drinking smokers
Fucito LM, Toll BA, Wu R, Romano DM, Tek E, O’Malley S. A preliminary investigation of varenicline for heavy drinking smokers. Psychopharmacology 2011, 215: 655-663. PMID: 21221531, PMCID: PMC3645986, DOI: 10.1007/s00213-010-2160-9.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersActive medicationPretreatment groupAlcohol cravingHeavy drinkersOpen-label phaseSmoking cessation pharmacotherapyEffects of vareniclineHeavy drinking daysGreater reductionPlacebo leadVarenicline pretreatmentCessation counselingCessation pharmacotherapyAbstinence ratesCigarette smokingVareniclineSmoking changesDrinking daysPotential treatmentSmokingAlcohol dependenceEntire study periodSmokersHeavy drinking
2009
Beliefs and Attitudes About Bupropion: Implications for Medication Adherence and Smoking Cessation Treatment
Fucito LM, Toll BA, Salovey P, O’Malley S. Beliefs and Attitudes About Bupropion: Implications for Medication Adherence and Smoking Cessation Treatment. Psychology Of Addictive Behaviors 2009, 23: 373-379. PMID: 19586156, PMCID: PMC3094849, DOI: 10.1037/a0015695.Peer-Reviewed Original ResearchConceptsPositive beliefsDisadvantages of smokingRole of beliefsTreatment adherenceSmoking cessation treatmentSmoking lapseSmoking cessation trialPreliminary supportCessation outcomesPositive attitudesCessation treatmentBetter treatment adherenceCessation trialBeliefsAttitudesMedication adherenceBupropion therapyBetter treatment responseGreater medication adherenceSecondary analysisMotivationTreatment responseIntentionBupropionLapse
2007
Effects of instructions on responses to the nicotine patch: a laboratory study
Fucito LM, Juliano LM. Effects of instructions on responses to the nicotine patch: a laboratory study. Psychopharmacology 2007, 194: 475-483. PMID: 17619862, DOI: 10.1007/s00213-007-0851-7.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdolescentAdultAffectAlgorithmsAnalysis of VarianceDose-Response Relationship, DrugFemaleHealth PromotionHumansMaleNicotineNicotinic AgonistsPatient Education as TopicProportional Hazards ModelsRecurrenceSex FactorsSmokingSmoking CessationSmoking PreventionTreatment OutcomeConceptsPlacebo patchNicotine patchSmoking behaviorAbstinence periodNicotine replacement therapyWomen's smoking behaviourSide effect informationReplacement therapyCessation outcomesAbstinence outcomesSubjective outcomesSide effectsObjectivesThis studyPlacebo instructionNicotine instructionsOutcomesNicotine contentConclusionsThe resultsEffect informationControl conditionExpectancyPositive expectanciesPreliminary studySmokersSmoking