2015
An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate
Gueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.Peer-Reviewed Original ResearchConceptsAcamprosate effectHeavy drinkingShort abstinenceEnhanced treatment responseMonths of treatmentSubgroup of patientsBody mass indexDrug plasma levelsIdentification of subgroupsBetter prognosisLower BMIMass indexPlasma levelsGlutamatergic hyperactivityTreatment responseAcamprosateCOMBINE StudyPrior treatmentLarger studyConsecutive daysAbstinencePretreatment abstinenceTreatment effectsCognitive inefficiencySubgroups
2014
Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT
Gueorguieva R, Wu R, O'Connor PG, Weisner C, Fucito LM, Hoffmann S, Mann K, O'Malley SS. Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT. Alcohol Clinical And Experimental Research 2014, 38: 2647-2656. PMID: 25346505, PMCID: PMC4397985, DOI: 10.1111/acer.12541.Peer-Reviewed Original ResearchAcamprosateAge FactorsAlcohol AbstinenceAlcohol DeterrentsAlcohol DrinkingBehavior TherapyCombined Modality TherapyControlled Clinical Trials as TopicDecision TreesGamma-GlutamyltransferaseGermanyGoalsHumansLogistic ModelsMiddle AgedNaltrexonePredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsTaurineTime FactorsTreatment OutcomeUnited StatesIn With the Old and Out With the New? A Comparison of the Old and New Binge Drinking Standards
Corbin WR, Zalewski S, Leeman RF, Toll BA, Fucito LM, O'Malley SS. In With the Old and Out With the New? A Comparison of the Old and New Binge Drinking Standards. Alcohol Clinical And Experimental Research 2014, 38: 2657-2663. PMID: 25346506, PMCID: PMC9328028, DOI: 10.1111/acer.12514.Peer-Reviewed Original ResearchConceptsIndex of intoxicationRandomized clinical trialsHeavy-drinking young adultsClinical trialsAlcohol abuseDrinking consequencesNegative drinking consequencesYoung adultsNational InstituteDrinking occasionsRiskConsistent evidenceIntoxicationRegression modelsTask ForceAdultsBrief measureDrinking sampleFurther effortsNegative consequencesBingeTrials
2012
Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence
Fucito LM, Park A, Gulliver SB, Mattson ME, Gueorguieva RV, O'Malley SS. Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence. Biological Psychiatry 2012, 72: 832-838. PMID: 22541040, PMCID: PMC3410039, DOI: 10.1016/j.biopsych.2012.03.023.Peer-Reviewed Original ResearchConceptsCigarette smokingAlcohol dependenceBehavioral interventionsAlcohol-dependent smokersCombination of medicationsBaseline demographic differencesPoor treatment outcomesPoor treatment responseDrinking outcomesBetter drinking outcomesSevere alcohol dependenceAlcohol-dependent individualsCigarette intakeAlcohol use outcomesMedical managementPharmacological treatmentTreatment outcomesTreatment responseSmokingSmokersCOMBINE StudyAlcoholism typologyDrinking-related variablesTreatment assignmentNonsmokers
2011
Co-occurring marijuana use is associated with medication nonadherence and nonplanning impulsivity in young adult heavy drinkers
Peters EN, Leeman RF, Fucito LM, Toll BA, Corbin WR, O'Malley SS. Co-occurring marijuana use is associated with medication nonadherence and nonplanning impulsivity in young adult heavy drinkers. Addictive Behaviors 2011, 37: 420-426. PMID: 22189052, PMCID: PMC3288288, DOI: 10.1016/j.addbeh.2011.11.036.Peer-Reviewed Original ResearchConceptsCo-occurring marijuana useAdult heavy drinkersYoung adult heavy drinkersHeavy drinkersMedication nonadherenceAlcohol consumptionHigh-risk clinical profileMarijuana useAlcohol-related negative consequencesUse of cigarettesAlcohol-induced disinhibitionBrief individual counselingClinical profileClinical trialsSelf-report assessmentsNonadherenceHeavy drinkingYoung adultsDemographic characteristicsDrinkersIndividual counselingClinical samplesHeavy alcoholMedicationsDrinking