2022
Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury
Shin NS, Marlier A, Xu L, Lam T, Cantley LG, Guo JK. Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury. American Journal Of Physiology. Renal Physiology 2022, 322: f322-f334. PMID: 35100823, PMCID: PMC8897010, DOI: 10.1152/ajprenal.00284.2021.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryCast formationGlomerular filtration rateTubular cast formationUrine 24 hDetached epithelial cellsDead cell debrisRenal recoveryRenal functionFiltration rateS3 tubulesTubular castsTubular cellsTubular nucleiKidney sectionsOuter medullaTrypsin levelsEntire nephronRenal tubular castsFuture interventionsInjurySelective lossTubule segmentsEpithelial cellsKidney
2014
Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm
Golden D, Cantley LG. Casein kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm. Oncogene 2014, 34: 4702-4712. PMID: 25486430, PMCID: PMC4459945, DOI: 10.1038/onc.2014.395.Peer-Reviewed Original ResearchConceptsCK2β regulatory subunitSerine 124Epithelial-mesenchymal transitionRegulatory subunitNuclear localizationCytoplasmic localizationCasein kinase 2 phosphorylation sitesDevelopmental epithelial-mesenchymal transitionMesenchymal transformationCell migrationEpithelial cellsDe novo accumulationCK2 associatesTranscriptional regulatorsMalignant breast cancer cellsPhosphorylation sitesCK2β expressionKinase subunitMesenchymal genesBreast epithelial cellsProper targetingAmino terminusNormal breast epithelial cellsNormal epithelial cellsLeucine promotesHepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling*
Koraishy FM, Silva C, Mason S, Wu D, Cantley LG. Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling*. Journal Of Biological Chemistry 2014, 289: 14341-14350. PMID: 24692544, PMCID: PMC4022900, DOI: 10.1074/jbc.m114.563213.Peer-Reviewed Original ResearchConceptsΒ-catenin stabilizationRenal ischemic injuryLRP5/6 phosphorylationEpithelial cell responsesRenal proximal tubulesEpithelial cell apoptosisHepatocyte growth factorCanonical WntActive GSK3Ischemic injuryRenal epithelial cellsProximal tubulesCell responsesCanonical Wnt signalingHGF treatmentGrowth factorCell apoptosisEpithelial cellsHGFMet receptorImportant transactivatorWnt signalingInjuryLRP5/6MetS
2001
HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner
Liu Z, Nickel C, Cantley L. HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. American Journal Of Physiology. Renal Physiology 2001, 281: f62-f70. PMID: 11399647, DOI: 10.1152/ajprenal.2001.281.1.f62.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseATP-depleted cellsHepatocyte growth factorCell adhesionAddition of HGFATP depletionExtracellular signal-regulated kinase (ERK) phosphorylationMAPK-dependent mannerSignal-regulated kinase phosphorylationLoss of adhesionDuct 3 cellsEffects of HGFProtein kinaseERK activationMAPK pathwayKinase phosphorylationRenal tubular epithelial cellsEpithelial cellsAdherent cellsGrowth factorCellsATPTubular epithelial cellsPathwayAdhesion
2000
Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.
O'Rourke DA, Liu ZX, Sellin L, Spokes K, Zeller R, Cantley L. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. Journal Of The American Society Of Nephrology 2000, 11: 2212-2221. PMID: 11095644, DOI: 10.1681/asn.v11122212.Peer-Reviewed Original ResearchConceptsFormin isoformsHepatocyte growth factorRenal epithelial cellsEpithelial tubule formationProtein kinase-dependent mannerUreteric bud outgrowthExtracellular signal-regulated kinaseQuiescent epithelial cellsEpithelial cellsFamily of proteinsProtein kinase inhibitor U0126Mitogen-activated protein kinase-dependent mannerKinase-dependent mannerMitogen-activated protein kinase inhibitor U0126Kinase inhibitor U0126Cell-matrix interactionsCell-cell interactionsGrowth factorSignal-regulated kinaseTubule formationSoluble cell lysateRapid relocalizationPhosphorylation substratesActin cytoskeletonCellular relocalization