2015
The Role of p204 in Kidney Injury
Marlier A, Huen S, Lengyel P, Cantley L. The Role of p204 in Kidney Injury. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.807.1.Peer-Reviewed Original ResearchAcute kidney injuryIschemia-reperfusion injuryRenal ischemia-reperfusion injuryChronic kidney diseaseKidney injuryPeak serum creatinine levelClassical inflammatory stimuliSerum creatinine levelsTubular cell necrosisCD45-positive cellsWhole-body knockoutAKI biomarkersCreatinine levelsKidney diseaseCHI3L1 expressionKidney ischemiaKidney fibrosisInflammasome activationInflammatory stimuliReparative phasePositive cellsTherapeutic targetBone marrowWT controlsCell necrosis
2013
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2
He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, Ma B, Herzog EL, Rosenberg SA, Li Y, Nour AM, Parikh CR, Schmidt I, Modis Y, Cantley L, Elias JA. Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2. Cell Reports 2013, 4: 830-841. PMID: 23972995, PMCID: PMC3988532, DOI: 10.1016/j.celrep.2013.07.032.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisChitinase-3-Like Protein 1GlycoproteinsHumansInflammasomesInterleukin-13Interleukin-13 Receptor alpha2 SubunitLung NeoplasmsMacrophagesMAP Kinase Signaling SystemMelanomaMiceMice, Inbred C57BLOxidative StressProtein BindingTransforming Growth Factor betaWnt Signaling PathwayConceptsProtein kinase B/AktWnt/β-catenin signalingΒ-catenin signalingCritical roleGene familyMultimeric complexesProtein kinaseMacrophage mitogenDisease toleranceCell deathAntibacterial responseReceptor α2Antipathogen responsesChitinase 3IL-13Rα2IL-13 receptor α2Inflammasome activationBacterial killingKinaseOxidant injuryReceptorsMelanoma metastasesCHI3L1SignalingAkt