2023
The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis
Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen P, Chandra N, Cantley L, Veselits M, Clark M, Craft J. The ion transporter Na+-K+-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Science Advances 2023, 9: eadf8156. PMID: 36724234, PMCID: PMC9891690, DOI: 10.1126/sciadv.adf8156.Peer-Reviewed Original ResearchConceptsB cellsAutoimmune diseasesAmelioration of proteinuriaLupus nephritis biopsiesB cell infiltrationSodium-potassium adenosine triphosphataseB cell survivalPotassium adenosine triphosphataseLupus nephritisCell infiltrationKidney microenvironmentTissue injuryTherapeutic targetPharmacological inhibitionElevated sodium concentrationLupusHostile microenvironmentHigh expressionKidneySodium concentrationGenetic knockoutCell survivalDiseaseCellsAdenosine triphosphatase
2015
The Role of p204 in Kidney Injury
Marlier A, Huen S, Lengyel P, Cantley L. The Role of p204 in Kidney Injury. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.807.1.Peer-Reviewed Original ResearchAcute kidney injuryIschemia-reperfusion injuryRenal ischemia-reperfusion injuryChronic kidney diseaseKidney injuryPeak serum creatinine levelClassical inflammatory stimuliSerum creatinine levelsTubular cell necrosisCD45-positive cellsWhole-body knockoutAKI biomarkersCreatinine levelsKidney diseaseCHI3L1 expressionKidney ischemiaKidney fibrosisInflammasome activationInflammatory stimuliReparative phasePositive cellsTherapeutic targetBone marrowWT controlsCell necrosis