2022
Interferon activated gene 204 protects against bone loss in experimental periodontitis
Swanson KV, Girnary M, Alves T, Ting JP, Divaris K, Beck J, Pucinelli CM, da Silva RAB, Uyan D, Wilson JE, Seaman WT, Webster‐Cyriaque J, Vias N, Jiao Y, Cantley L, Marlier A, Arnold RR, Marchesan JT. Interferon activated gene 204 protects against bone loss in experimental periodontitis. Journal Of Periodontology 2022, 93: 1366-1377. PMID: 35404474, PMCID: PMC9489626, DOI: 10.1002/jper.21-0668.Peer-Reviewed Original ResearchConceptsBone lossHuman endothelial cellsOsteoclast numberPeriodontal pathogensRecent human genetic association studiesHigher alveolar bone lossEndothelial cellsPeriodontal disease biomarkersAlveolar bone lossNeutrophils/macrophagesInterferon gamma-inducible protein 16Inflammatory cell traffickingInducible protein 16Periodontitis developmentChemokine responsesExperimental periodontitisInflammatory infiltrationPeriodontal destructionMarrow sourcesGingival tissuesMelanoma 2Periodontal tissuesLigature modelChimeric miceAlveolar bone
2013
Brg1 Determines Urothelial Cell Fate during Ureter Development
Weiss RM, Guo S, Shan A, Shi H, Romano RA, Sinha S, Cantley LG, Guo JK. Brg1 Determines Urothelial Cell Fate during Ureter Development. Journal Of The American Society Of Nephrology 2013, 24: 618-626. PMID: 23449535, PMCID: PMC3609140, DOI: 10.1681/asn.2012090902.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsUreter developmentBasal cell populationUreteral smooth muscle cellsHoxb7-CreTerminal differentiationPPARγ expressionUreteral epitheliumMuscle cellsUrothelial cellsP63 expressionRole of BRG1Basal cellsUmbrella cellsCell populationsSonic hedgehog expressionEpithelial stratificationAdult ureterUreterCell developmentBRG1 expressionSmooth muscle cell developmentShh expressionCellsHedgehog expression
2001
ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*
Yu C, Roshan B, Liu Z, Cantley L. ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*. Journal Of Biological Chemistry 2001, 276: 32552-32558. PMID: 11445578, DOI: 10.1074/jbc.m104493200.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBinding SitesButadienesCell LineCulture Media, Serum-FreeEnzyme ActivationEnzyme InhibitorsEpithelial CellsHepatocyte Growth FactorKineticsMitogen-Activated Protein KinasesNitrilesPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphopeptidesPhosphoproteinsPhosphothreoninePhosphotyrosineProtein SubunitsRecombinant Fusion ProteinsSrc Homology Domains
1999
Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1*
Roshan B, Kjelsberg C, Spokes K, Eldred A, Crovello C, Cantley L. Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1*. Journal Of Biological Chemistry 1999, 274: 36362-36368. PMID: 10593929, DOI: 10.1074/jbc.274.51.36362.Peer-Reviewed Original Research