1998
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*
Rameh L, Rhee S, Spokes K, Kazlauskas A, Cantley L, Cantley L. Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*. Journal Of Biological Chemistry 1998, 273: 23750-23757. PMID: 9726983, DOI: 10.1074/jbc.273.37.23750.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesBinding SitesCalciumChromonesEnzyme InhibitorsHumansIsoenzymesKineticsMorpholinesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C gammaPlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth FactorRecombinant Fusion ProteinsSignal TransductionTransfectionTumor Cells, CulturedType C PhospholipasesWortmanninConceptsPlatelet-derived growth factor receptorIntracellular calcium releaseCalcium releasePI3KGrowth factor receptorIntracellular calciumIP3 generationInositol trisphosphate generationIP3 productionFactor receptorVivo relevanceCalcium signalingTrisphosphate generationHepG2 cellsSelective activationAddition of wortmanninPhospholipase Cγ
1997
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*
Derman M, Toker A, Hartwig J, Spokes K, Falck JR, Chen C, Cantley L, Cantley L. The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*. Journal Of Biological Chemistry 1997, 272: 6465-6470. PMID: 9045671, DOI: 10.1074/jbc.272.10.6465.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAndrostadienesAnimalsCell MembraneCell MovementDown-RegulationEnzyme ActivationEnzyme InhibitorsMiceNaphthalenesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorProtein Kinase CSignal TransductionWortmanninConceptsProtein kinase CCell motilityLipid productsKinase CPKC family membersNIH 3T3 cellsIndependent PKC isoformsMembrane rufflingActin reorganizationCellular motilityPKC isoformsPtdInsVivo rolePhosphoinositideMotilityFirst demonstrationRecent studiesFamily membersComplete inhibitionCellsRufflingPhosphatidylinositolPrevious observationsIsoformsTrisphosphate
1996
An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗)
Derman M, Chen J, Spokes K, Songyang Z, Cantley L. An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗). Journal Of Biological Chemistry 1996, 271: 4251-4255. PMID: 8626770, DOI: 10.1074/jbc.271.8.4251.Peer-Reviewed Original Research3T3 CellsAmino Acid SequenceAnimalsCell LineChemotaxisCloning, MolecularEpitheliumHepatocyte Growth FactorKidney TubulesMiceMolecular Sequence DataPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorPoint MutationProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Platelet-Derived Growth FactorRecombinant ProteinsTransfectionType C Phospholipases