2014
Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling*
Koraishy FM, Silva C, Mason S, Wu D, Cantley LG. Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling*. Journal Of Biological Chemistry 2014, 289: 14341-14350. PMID: 24692544, PMCID: PMC4022900, DOI: 10.1074/jbc.m114.563213.Peer-Reviewed Original ResearchConceptsΒ-catenin stabilizationRenal ischemic injuryLRP5/6 phosphorylationEpithelial cell responsesRenal proximal tubulesEpithelial cell apoptosisHepatocyte growth factorCanonical WntActive GSK3Ischemic injuryRenal epithelial cellsProximal tubulesCell responsesCanonical Wnt signalingHGF treatmentGrowth factorCell apoptosisEpithelial cellsHGFMet receptorImportant transactivatorWnt signalingInjuryLRP5/6MetS
2001
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud
Karihaloo A, Karumanchi S, Barasch J, Jha V, Nickel C, Yang J, Grisaru S, Bush K, Nigam S, Rosenblum N, Sukhatme V, Cantley L. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12509-12514. PMID: 11606725, PMCID: PMC60084, DOI: 10.1073/pnas.221205198.Peer-Reviewed Original ResearchERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*
Yu C, Roshan B, Liu Z, Cantley L. ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*. Journal Of Biological Chemistry 2001, 276: 32552-32558. PMID: 11445578, DOI: 10.1074/jbc.m104493200.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBinding SitesButadienesCell LineCulture Media, Serum-FreeEnzyme ActivationEnzyme InhibitorsEpithelial CellsHepatocyte Growth FactorKineticsMitogen-Activated Protein KinasesNitrilesPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphopeptidesPhosphoproteinsPhosphothreoninePhosphotyrosineProtein SubunitsRecombinant Fusion ProteinsSrc Homology DomainsHGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner
Liu Z, Nickel C, Cantley L. HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. American Journal Of Physiology. Renal Physiology 2001, 281: f62-f70. PMID: 11399647, DOI: 10.1152/ajprenal.2001.281.1.f62.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseATP-depleted cellsHepatocyte growth factorCell adhesionAddition of HGFATP depletionExtracellular signal-regulated kinase (ERK) phosphorylationMAPK-dependent mannerSignal-regulated kinase phosphorylationLoss of adhesionDuct 3 cellsEffects of HGFProtein kinaseERK activationMAPK pathwayKinase phosphorylationRenal tubular epithelial cellsEpithelial cellsAdherent cellsGrowth factorCellsATPTubular epithelial cellsPathwayAdhesion
2000
Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*
Karihaloo A, O'Rourke D, Nickel C, Spokes K, Cantley L. Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*. Journal Of Biological Chemistry 2000, 276: 9166-9173. PMID: 11118451, DOI: 10.1074/jbc.m009963200.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TransformedCell MovementEpidermal Growth FactorHepatocyte Growth FactorKidneyMitogen-Activated Protein KinasesMorphogenesisConceptsHepatocyte growth factorP42/44 mitogen-activated protein kinase (MAPK) pathwayEGF-induced cell motilityProtein kinase kinase inhibitor PD98059Mitogen-activated protein kinase kinase inhibitor PD98059Mitogen-activated protein kinase pathwayEGF-dependent migrationProcess formationEGF-stimulated cellsRenal epithelial morphogenesisIndependent signaling pathwaysKinase inhibitor PD98059ERK1/ERK2Protein kinase pathwayEpidermal growth factor receptor ligandsCultured renal epithelial cellsLigand hepatocyte growth factorGrowth factor receptor ligandsCell morphogenesisEpithelial morphogenesisRenal epithelial cellsMKK1 inhibitorCell motilityKinase pathwayInhibitor PD98059Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.
O'Rourke DA, Liu ZX, Sellin L, Spokes K, Zeller R, Cantley L. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. Journal Of The American Society Of Nephrology 2000, 11: 2212-2221. PMID: 11095644, DOI: 10.1681/asn.v11122212.Peer-Reviewed Original ResearchConceptsFormin isoformsHepatocyte growth factorRenal epithelial cellsEpithelial tubule formationProtein kinase-dependent mannerUreteric bud outgrowthExtracellular signal-regulated kinaseQuiescent epithelial cellsEpithelial cellsFamily of proteinsProtein kinase inhibitor U0126Mitogen-activated protein kinase-dependent mannerKinase-dependent mannerMitogen-activated protein kinase inhibitor U0126Kinase inhibitor U0126Cell-matrix interactionsCell-cell interactionsGrowth factorSignal-regulated kinaseTubule formationSoluble cell lysateRapid relocalizationPhosphorylation substratesActin cytoskeletonCellular relocalization
1999
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells
O’Rourke D, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L. Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. American Journal Of Physiology 1999, 276: f581-f588. PMID: 10198418, DOI: 10.1152/ajprenal.1999.276.4.f581.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell SurvivalCollagenDogsDrosophila ProteinsEpithelial CellsGlial Cell Line-Derived Neurotrophic Factor ReceptorsHepatocyte Growth FactorKidneyKidney MedullaKidney Tubules, CollectingMicePhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesConceptsGlial-derived neurotropic factorCell survivalEpidermal growth factorC-RetHepatocyte growth factorProtein tyrosine kinase receptorsEpithelial cell morphogenesisEarly branching morphogenesisTyrosine-phosphorylated receptorsUreteric bud developmentProcess formationSpiny cystsCell morphogenesisTyrosine kinase receptorsEpithelial morphogenesisGrowth factorBranching morphogenesisExamination of mRNAEGF receptorMorphogenesisStable expressionKinase receptorsBud developmentSerum-free conditionsEarly regulation
1996
An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗)
Derman M, Chen J, Spokes K, Songyang Z, Cantley L. An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (∗). Journal Of Biological Chemistry 1996, 271: 4251-4255. PMID: 8626770, DOI: 10.1074/jbc.271.8.4251.Peer-Reviewed Original Research3T3 CellsAmino Acid SequenceAnimalsCell LineChemotaxisCloning, MolecularEpitheliumHepatocyte Growth FactorKidney TubulesMiceMolecular Sequence DataPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorPoint MutationProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptor Protein-Tyrosine KinasesReceptors, Platelet-Derived Growth FactorRecombinant ProteinsTransfectionType C Phospholipases