2001
ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*
Yu C, Roshan B, Liu Z, Cantley L. ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*. Journal Of Biological Chemistry 2001, 276: 32552-32558. PMID: 11445578, DOI: 10.1074/jbc.m104493200.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBinding SitesButadienesCell LineCulture Media, Serum-FreeEnzyme ActivationEnzyme InhibitorsEpithelial CellsHepatocyte Growth FactorKineticsMitogen-Activated Protein KinasesNitrilesPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphopeptidesPhosphoproteinsPhosphothreoninePhosphotyrosineProtein SubunitsRecombinant Fusion ProteinsSrc Homology Domains
1998
Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate*
Bae Y, Cantley L, Chen C, Kim S, Kwon K, Rhee S. Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate*. Journal Of Biological Chemistry 1998, 273: 4465-4469. PMID: 9468499, DOI: 10.1074/jbc.273.8.4465.Peer-Reviewed Original ResearchConceptsPLC-gamma isozymesPhospholipase CSrc homology 2 domainNIH 3T3 cellsCOS-7 cellsSpecific phospholipase CPLC gamma tyrosine phosphorylationAction of PISignal transductionCatalytic subunitTyrosine phosphorylationSpecific PIInhibitor LY294002PLC activationCell membranePhosphatidylinositolInositol phosphate formationIsozymesActivationCellsTransductionPIPhosphorylationSubunitsBisphosphate