2020
Polycystin 2 is increased in disease to protect against stress-induced cell death
Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE. Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports 2020, 10: 386. PMID: 31941974, PMCID: PMC6962458, DOI: 10.1038/s41598-019-57286-x.Peer-Reviewed Original ResearchConceptsPolycystin-2General cellular homeostasisCell deathStress-induced cell deathPathological cell deathAutosomal dominant polycystic kidney diseaseEndoplasmic reticulum membraneCellular homeostasisCellular stressPrimary ciliaUbiquitous expressionExpression changesCell stressReticulum membraneTransient receptor potential cation channelHuman diseasesMultiple tissuesEndogenous roleDominant polycystic kidney diseaseTissue typesCation channelsPolycystic kidney diseaseDifferent pathological statesMultiple diseasesKidney disease
1998
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*
Rameh L, Rhee S, Spokes K, Kazlauskas A, Cantley L, Cantley L. Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*. Journal Of Biological Chemistry 1998, 273: 23750-23757. PMID: 9726983, DOI: 10.1074/jbc.273.37.23750.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesBinding SitesCalciumChromonesEnzyme InhibitorsHumansIsoenzymesKineticsMorpholinesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C gammaPlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth FactorRecombinant Fusion ProteinsSignal TransductionTransfectionTumor Cells, CulturedType C PhospholipasesWortmanninConceptsPlatelet-derived growth factor receptorIntracellular calcium releaseCalcium releasePI3KGrowth factor receptorIntracellular calciumIP3 generationInositol trisphosphate generationIP3 productionFactor receptorVivo relevanceCalcium signalingTrisphosphate generationHepG2 cellsSelective activationAddition of wortmanninPhospholipase Cγ