2001
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud
Karihaloo A, Karumanchi S, Barasch J, Jha V, Nickel C, Yang J, Grisaru S, Bush K, Nigam S, Rosenblum N, Sukhatme V, Cantley L. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12509-12514. PMID: 11606725, PMCID: PMC60084, DOI: 10.1073/pnas.221205198.Peer-Reviewed Original ResearchCell Surface Glypicans Are Low-Affinity Endostatin Receptors
Karumanchi S, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai J, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen R, Lander A, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme V. Cell Surface Glypicans Are Low-Affinity Endostatin Receptors. Molecular Cell 2001, 7: 811-822. PMID: 11336704, DOI: 10.1016/s1097-2765(01)00225-8.Peer-Reviewed Original ResearchConceptsHeparan sulfate glycosaminoglycansPotent anti-angiogenic proteinCell surface proteoglycansBranching morphogenesisEndothelial cellsGenetic studiesGlypicansExpression cloningSurface proteoglycansAntisense experimentsCell surfaceAnti-angiogenic proteinEndothelial cell surfaceLow-affinity receptorsSulfate glycosaminoglycansEndostatin bindingCellsReceptorsMorphogenesisEndostatin activityCloningProteinEndostatinBindingProteoglycans
2000
Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome*
Kalluri R, Cantley L, Kerjaschki D, Neilson E. Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome*. Journal Of Biological Chemistry 2000, 275: 20027-20032. PMID: 10748075, DOI: 10.1074/jbc.m904549199.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Glomerular Basement Membrane DiseaseAutoantibodiesBasement MembraneCollagenDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayEpitopesFluorescent Antibody TechniqueHumansHydrogen PeroxideKidneyMiceMice, Inbred BALB CProtein Structure, TertiaryRatsReactive Oxygen SpeciesTime FactorsConceptsGoodpasture's syndromeReactive oxygen speciesGoodpasture epitopeType IV collagenRenal transplant recipientsIV collagenEffects of ROSTime-dependent fashionTransplant recipientsNeoantigen formationAutoantibody productionImmune activationAutoimmune diseasesHydrogen peroxide administrationAge-dependent deteriorationT cellsNon-collagenous globular domainsImmune systemEpitope diversityCryptic epitopesSyndromeAlport syndromeHeterologous antibodiesGoodpasture antibodyEpitopes
1997
Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work
Joannidis M, Cantley L, Spokes K, Stuart-Tilley A, Alper S, Epstein F. Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work. Kidney International 1997, 52: 130-139. PMID: 9211355, DOI: 10.1038/ki.1997.312.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsBlotting, NorthernCell HypoxiaCells, CulturedDNA-Binding ProteinsDogsEarly Growth Response Protein 1Fluorescent Antibody Technique, IndirectGene Expression RegulationGlycineImmediate-Early ProteinsImmunohistochemistryIn Vitro TechniquesKidneyMaleOuabainProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyTime FactorsTranscription FactorsConceptsMedullary thick ascending limbThick ascending limbHypoxic injuryOuter medullaStandard perfusionC-fosMRNA levelsIEG expressionAscending limbEgr-1Immediate early gene c-fosAbsence of reperfusionEarly gene c-fosKrebs-Henseleit bufferGene c-fosImmediate early gene expressionInhibition of NaEgr-1 expressionHypoxic damageRenal cortexImmunohistochemical demonstrationRenal epithelial cellsTubular transportCultured renal epithelial cellsIEG mRNA levels
1996
Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney
Medina R, Cantley L, Spokes K, Epstein F. Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney. Kidney International 1996, 50: 1191-1194. PMID: 8887277, DOI: 10.1038/ki.1996.427.Peer-Reviewed Original Research
1995
Induction of heat-shock proteins does not prevent renal tubular injury following ischemia
Joannidis M, Cantley L, Spokes K, Medina R, Pullman J, Rosen S, Epstein F. Induction of heat-shock proteins does not prevent renal tubular injury following ischemia. Kidney International 1995, 47: 1752-1759. PMID: 7643546, DOI: 10.1038/ki.1995.242.Peer-Reviewed Original ResearchConceptsHeat shock proteinsMedullary hypoxic injuryPossible protective effectRenal tubular injuryDifferent experimental modelsSevere morphological damageSerum creatinineTubular injuryCross clampingIschemic injuryRight kidneyRenal arteryHypoxic injuryControl ratsIntact ratsRenal cortexProtective effectImmunohistochemical meansUrea nitrogenProximal tubulesHeat shockRenal cellsRat kidneyKidneyMorphological damage
1993
Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction
Cantley L, Spokes K, Clark B, McMahon E, Carter J, Epstein F. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. Kidney International 1993, 44: 1217-1223. PMID: 8301922, DOI: 10.1038/ki.1993.371.Peer-Reviewed Original ResearchConceptsRenal blood flowRole of endothelinRenal artery constrictionEndothelin receptor antagonistsBlood flowRenal vasoconstrictionArtery constrictionReceptor antagonistSystemic blood pressureUrinary prostaglandin E2Absence of indomethacinRenal hypoperfusionBlood pressureRenal perfusionAortic ringsIntact ratsProstaglandin E2Sustained decreaseNormal ratsRadiocontrast agentsBaseline valuesProstaglandin synthesisProstaglandin formationRatsIndomethacinEffects of Ioversol versus Iothalamate on Endothelin Release and Radiocontrast Nephropathy
HEYMAN S, CLARK B, CANTLEY L, SPOKES K, ROSEN S, BREZIS M, EPSTEIN F. Effects of Ioversol versus Iothalamate on Endothelin Release and Radiocontrast Nephropathy. Investigative Radiology 1993, 28: 313-318. PMID: 8478171, DOI: 10.1097/00004424-199304000-00011.Peer-Reviewed Original ResearchConceptsEffects of ioversolEndothelin releaseRadiocontrast nephropathyRadiocontrast agentsEqui-iodine dosesRelease of endothelinLow-osmolar agentsCultured bovine aortic endothelial cellsAortic endothelial cellsRenal vasoconstrictionBovine aortic endothelial cellsRenal vasoconstrictorCreatinine clearanceRenal functionOsmolar agentsRenal toxicityMorphologic damageNormal ratsVascular endotheliumSalt depletionNephropathyRenal medullaRatsEndothelial cellsIoversol