Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*
Karihaloo A, O'Rourke D, Nickel C, Spokes K, Cantley L. Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis*. Journal Of Biological Chemistry 2000, 276: 9166-9173. PMID: 11118451, DOI: 10.1074/jbc.m009963200.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TransformedCell MovementEpidermal Growth FactorHepatocyte Growth FactorKidneyMitogen-Activated Protein KinasesMorphogenesisConceptsHepatocyte growth factorP42/44 mitogen-activated protein kinase (MAPK) pathwayEGF-induced cell motilityProtein kinase kinase inhibitor PD98059Mitogen-activated protein kinase kinase inhibitor PD98059Mitogen-activated protein kinase pathwayEGF-dependent migrationProcess formationEGF-stimulated cellsRenal epithelial morphogenesisIndependent signaling pathwaysKinase inhibitor PD98059ERK1/ERK2Protein kinase pathwayEpidermal growth factor receptor ligandsCultured renal epithelial cellsLigand hepatocyte growth factorGrowth factor receptor ligandsCell morphogenesisEpithelial morphogenesisRenal epithelial cellsMKK1 inhibitorCell motilityKinase pathwayInhibitor PD98059Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells.
O'Rourke DA, Liu ZX, Sellin L, Spokes K, Zeller R, Cantley L. Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. Journal Of The American Society Of Nephrology 2000, 11: 2212-2221. PMID: 11095644, DOI: 10.1681/asn.v11122212.Peer-Reviewed Original ResearchConceptsFormin isoformsHepatocyte growth factorRenal epithelial cellsEpithelial tubule formationProtein kinase-dependent mannerUreteric bud outgrowthExtracellular signal-regulated kinaseQuiescent epithelial cellsEpithelial cellsFamily of proteinsProtein kinase inhibitor U0126Mitogen-activated protein kinase-dependent mannerKinase-dependent mannerMitogen-activated protein kinase inhibitor U0126Kinase inhibitor U0126Cell-matrix interactionsCell-cell interactionsGrowth factorSignal-regulated kinaseTubule formationSoluble cell lysateRapid relocalizationPhosphorylation substratesActin cytoskeletonCellular relocalization