2001
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud
Karihaloo A, Karumanchi S, Barasch J, Jha V, Nickel C, Yang J, Grisaru S, Bush K, Nigam S, Rosenblum N, Sukhatme V, Cantley L. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12509-12514. PMID: 11606725, PMCID: PMC60084, DOI: 10.1073/pnas.221205198.Peer-Reviewed Original ResearchCell Surface Glypicans Are Low-Affinity Endostatin Receptors
Karumanchi S, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai J, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen R, Lander A, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme V. Cell Surface Glypicans Are Low-Affinity Endostatin Receptors. Molecular Cell 2001, 7: 811-822. PMID: 11336704, DOI: 10.1016/s1097-2765(01)00225-8.Peer-Reviewed Original ResearchConceptsHeparan sulfate glycosaminoglycansPotent anti-angiogenic proteinCell surface proteoglycansBranching morphogenesisEndothelial cellsGenetic studiesGlypicansExpression cloningSurface proteoglycansAntisense experimentsCell surfaceAnti-angiogenic proteinEndothelial cell surfaceLow-affinity receptorsSulfate glycosaminoglycansEndostatin bindingCellsReceptorsMorphogenesisEndostatin activityCloningProteinEndostatinBindingProteoglycans
2000
Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome*
Kalluri R, Cantley L, Kerjaschki D, Neilson E. Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome*. Journal Of Biological Chemistry 2000, 275: 20027-20032. PMID: 10748075, DOI: 10.1074/jbc.m904549199.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Glomerular Basement Membrane DiseaseAutoantibodiesBasement MembraneCollagenDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayEpitopesFluorescent Antibody TechniqueHumansHydrogen PeroxideKidneyMiceMice, Inbred BALB CProtein Structure, TertiaryRatsReactive Oxygen SpeciesTime FactorsConceptsGoodpasture's syndromeReactive oxygen speciesGoodpasture epitopeType IV collagenRenal transplant recipientsIV collagenEffects of ROSTime-dependent fashionTransplant recipientsNeoantigen formationAutoantibody productionImmune activationAutoimmune diseasesHydrogen peroxide administrationAge-dependent deteriorationT cellsNon-collagenous globular domainsImmune systemEpitope diversityCryptic epitopesSyndromeAlport syndromeHeterologous antibodiesGoodpasture antibodyEpitopes
1999
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells
O’Rourke D, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L. Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. American Journal Of Physiology 1999, 276: f581-f588. PMID: 10198418, DOI: 10.1152/ajprenal.1999.276.4.f581.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell SurvivalCollagenDogsDrosophila ProteinsEpithelial CellsGlial Cell Line-Derived Neurotrophic Factor ReceptorsHepatocyte Growth FactorKidneyKidney MedullaKidney Tubules, CollectingMicePhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesConceptsGlial-derived neurotropic factorCell survivalEpidermal growth factorC-RetHepatocyte growth factorProtein tyrosine kinase receptorsEpithelial cell morphogenesisEarly branching morphogenesisTyrosine-phosphorylated receptorsUreteric bud developmentProcess formationSpiny cystsCell morphogenesisTyrosine kinase receptorsEpithelial morphogenesisGrowth factorBranching morphogenesisExamination of mRNAEGF receptorMorphogenesisStable expressionKinase receptorsBud developmentSerum-free conditionsEarly regulation