1999
Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1*
Roshan B, Kjelsberg C, Spokes K, Eldred A, Crovello C, Cantley L. Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1*. Journal Of Biological Chemistry 1999, 274: 36362-36368. PMID: 10593929, DOI: 10.1074/jbc.274.51.36362.Peer-Reviewed Original ResearchExpression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells
O’Rourke D, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L. Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. American Journal Of Physiology 1999, 276: f581-f588. PMID: 10198418, DOI: 10.1152/ajprenal.1999.276.4.f581.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementCell SurvivalCollagenDogsDrosophila ProteinsEpithelial CellsGlial Cell Line-Derived Neurotrophic Factor ReceptorsHepatocyte Growth FactorKidneyKidney MedullaKidney Tubules, CollectingMicePhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesConceptsGlial-derived neurotropic factorCell survivalEpidermal growth factorC-RetHepatocyte growth factorProtein tyrosine kinase receptorsEpithelial cell morphogenesisEarly branching morphogenesisTyrosine-phosphorylated receptorsUreteric bud developmentProcess formationSpiny cystsCell morphogenesisTyrosine kinase receptorsEpithelial morphogenesisGrowth factorBranching morphogenesisExamination of mRNAEGF receptorMorphogenesisStable expressionKinase receptorsBud developmentSerum-free conditionsEarly regulation
1997
Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work
Joannidis M, Cantley L, Spokes K, Stuart-Tilley A, Alper S, Epstein F. Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work. Kidney International 1997, 52: 130-139. PMID: 9211355, DOI: 10.1038/ki.1997.312.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsBlotting, NorthernCell HypoxiaCells, CulturedDNA-Binding ProteinsDogsEarly Growth Response Protein 1Fluorescent Antibody Technique, IndirectGene Expression RegulationGlycineImmediate-Early ProteinsImmunohistochemistryIn Vitro TechniquesKidneyMaleOuabainProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyTime FactorsTranscription FactorsConceptsMedullary thick ascending limbThick ascending limbHypoxic injuryOuter medullaStandard perfusionC-fosMRNA levelsIEG expressionAscending limbEgr-1Immediate early gene c-fosAbsence of reperfusionEarly gene c-fosKrebs-Henseleit bufferGene c-fosImmediate early gene expressionInhibition of NaEgr-1 expressionHypoxic damageRenal cortexImmunohistochemical demonstrationRenal epithelial cellsTubular transportCultured renal epithelial cellsIEG mRNA levels