2001
ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*
Yu C, Roshan B, Liu Z, Cantley L. ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase*. Journal Of Biological Chemistry 2001, 276: 32552-32558. PMID: 11445578, DOI: 10.1074/jbc.m104493200.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBinding SitesButadienesCell LineCulture Media, Serum-FreeEnzyme ActivationEnzyme InhibitorsEpithelial CellsHepatocyte Growth FactorKineticsMitogen-Activated Protein KinasesNitrilesPeptide FragmentsPhosphatidylinositol 3-KinasesPhosphopeptidesPhosphoproteinsPhosphothreoninePhosphotyrosineProtein SubunitsRecombinant Fusion ProteinsSrc Homology DomainsHGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner
Liu Z, Nickel C, Cantley L. HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. American Journal Of Physiology. Renal Physiology 2001, 281: f62-f70. PMID: 11399647, DOI: 10.1152/ajprenal.2001.281.1.f62.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseATP-depleted cellsHepatocyte growth factorCell adhesionAddition of HGFATP depletionExtracellular signal-regulated kinase (ERK) phosphorylationMAPK-dependent mannerSignal-regulated kinase phosphorylationLoss of adhesionDuct 3 cellsEffects of HGFProtein kinaseERK activationMAPK pathwayKinase phosphorylationRenal tubular epithelial cellsEpithelial cellsAdherent cellsGrowth factorCellsATPTubular epithelial cellsPathwayAdhesion
1998
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*
Rameh L, Rhee S, Spokes K, Kazlauskas A, Cantley L, Cantley L. Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling*. Journal Of Biological Chemistry 1998, 273: 23750-23757. PMID: 9726983, DOI: 10.1074/jbc.273.37.23750.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesBinding SitesCalciumChromonesEnzyme InhibitorsHumansIsoenzymesKineticsMorpholinesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhospholipase C gammaPlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth FactorRecombinant Fusion ProteinsSignal TransductionTransfectionTumor Cells, CulturedType C PhospholipasesWortmanninConceptsPlatelet-derived growth factor receptorIntracellular calcium releaseCalcium releasePI3KGrowth factor receptorIntracellular calciumIP3 generationInositol trisphosphate generationIP3 productionFactor receptorVivo relevanceCalcium signalingTrisphosphate generationHepG2 cellsSelective activationAddition of wortmanninPhospholipase Cγ
1997
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*
Derman M, Toker A, Hartwig J, Spokes K, Falck JR, Chen C, Cantley L, Cantley L. The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C*. Journal Of Biological Chemistry 1997, 272: 6465-6470. PMID: 9045671, DOI: 10.1074/jbc.272.10.6465.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAndrostadienesAnimalsCell MembraneCell MovementDown-RegulationEnzyme ActivationEnzyme InhibitorsMiceNaphthalenesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)Platelet-Derived Growth FactorProtein Kinase CSignal TransductionWortmanninConceptsProtein kinase CCell motilityLipid productsKinase CPKC family membersNIH 3T3 cellsIndependent PKC isoformsMembrane rufflingActin reorganizationCellular motilityPKC isoformsPtdInsVivo rolePhosphoinositideMotilityFirst demonstrationRecent studiesFamily membersComplete inhibitionCellsRufflingPhosphatidylinositolPrevious observationsIsoformsTrisphosphate