2011
Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair
Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi BS, Ruhrberg C, Cantley LG. Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair. Journal Of The American Society Of Nephrology 2011, 22: 317-326. PMID: 21289217, PMCID: PMC3029904, DOI: 10.1681/asn.2009060615.Peer-Reviewed Original ResearchConceptsTubular cell proliferationProinflammatory macrophagesM2 phenotypeKidney injuryKidney repairInterstitial inflammatory cell infiltrateIschemia/reperfusion injuryRenal tubular cell proliferationTubular cell necrosisInflammatory cell infiltrateMacrophage-depleted miceDepletion of macrophagesIschemia/reperfusionBone marrow-derived macrophagesCell proliferationRenal tubular cellsMarrow-derived macrophagesAppearance of macrophagesLater time pointsKidney reperfusionTubule injuryCell infiltrateReperfusion injuryKidney damageMacrophage depletion
2000
Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome*
Kalluri R, Cantley L, Kerjaschki D, Neilson E. Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome*. Journal Of Biological Chemistry 2000, 275: 20027-20032. PMID: 10748075, DOI: 10.1074/jbc.m904549199.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Glomerular Basement Membrane DiseaseAutoantibodiesBasement MembraneCollagenDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayEpitopesFluorescent Antibody TechniqueHumansHydrogen PeroxideKidneyMiceMice, Inbred BALB CProtein Structure, TertiaryRatsReactive Oxygen SpeciesTime FactorsConceptsGoodpasture's syndromeReactive oxygen speciesGoodpasture epitopeType IV collagenRenal transplant recipientsIV collagenEffects of ROSTime-dependent fashionTransplant recipientsNeoantigen formationAutoantibody productionImmune activationAutoimmune diseasesHydrogen peroxide administrationAge-dependent deteriorationT cellsNon-collagenous globular domainsImmune systemEpitope diversityCryptic epitopesSyndromeAlport syndromeHeterologous antibodiesGoodpasture antibodyEpitopes