Monomeric Yeast PCNA Mutants Are Defective in Interacting with and Stimulating the ATPase Activity of RFC †
Ionescu CN, Shea KA, Mehra R, Prundeanu L, McAlear MA. Monomeric Yeast PCNA Mutants Are Defective in Interacting with and Stimulating the ATPase Activity of RFC †. Biochemistry 2002, 41: 12975-12985. PMID: 12390024, DOI: 10.1021/bi026029s.Peer-Reviewed Original ResearchConceptsReplication factor CMutant PCNAsDNA clampDNA damaging agent methylmethane sulfonateDNA polymerase accessory proteinMutant PCNA proteinsAgent methylmethane sulfonatePolymerase accessory proteinsProtein-protein interactionsWild-type subunitsSingle amino acid substitutionDNA repair pathwaysATPase activityE. coliAmino acid substitutionsYeast PCNAPCNA mutantsClamp loaderPCNA functionPCNA trimerBeta clampAccessory proteinsRepair pathwaysMethylmethane sulfonateAdjacent subunits