CUTS: A Deep Learning and Topological Framework for Multigranular Unsupervised Medical Image Segmentation
Liu C, Amodio M, Shen L, Gao F, Avesta A, Aneja S, Wang J, Del Priore L, Krishnaswamy S. CUTS: A Deep Learning and Topological Framework for Multigranular Unsupervised Medical Image Segmentation. Lecture Notes In Computer Science 2024, 15008: 155-165. DOI: 10.1007/978-3-031-72111-3_15.Peer-Reviewed Original ResearchMedical image segmentationImage segmentationLack of labeled dataUnsupervised deep learning frameworkSegmenting medical imagesDeep learning frameworkBrain MRI imagesRetinal fundus imagesContrastive learningLearning frameworkUnsupervised methodDeep learningExpert annotationsData topologyMedical imagesGranularity levelsEmbedding mapHausdorff distanceFundus imagesDice coefficientImage dataEmbeddingAnnotationLearningMRI imagesLong-term natural history of ellipsoid zone width in USH2A-retinopathy
Heyang M, Warren J, Ocieczek P, Duncan J, Moosajee M, Del Priore L, Shen L. Long-term natural history of ellipsoid zone width in USH2A-retinopathy. British Journal Of Ophthalmology 2024, bjo-2024-325323. PMID: 39103200, DOI: 10.1136/bjo-2024-325323.Peer-Reviewed Original ResearchTo Treat or Not to Treat Geographic Atrophy – That is the Question
Del Priore L. To Treat or Not to Treat Geographic Atrophy – That is the Question. Ophthalmology Retina 2024, 8: 207-209. PMID: 38448115, DOI: 10.1016/j.oret.2023.12.008.Peer-Reviewed Original ResearchPhenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health
Zekavat S, Jorshery S, Rauscher F, Horn K, Sekimitsu S, Koyama S, Nguyen T, Costanzo M, Jang D, Burtt N, Kühnapfel A, Shweikh Y, Ye Y, Raghu V, Zhao H, Ghassemi M, Elze T, Segrè A, Wiggs J, Del Priore L, Scholz M, Wang J, Natarajan P, Zebardast N. Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Science Translational Medicine 2024, 16: eadg4517. PMID: 38266105, DOI: 10.1126/scitranslmed.adg4517.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesRetinal layer thicknessPhotoreceptor segmentsOptical coherence tomographyRetinal layersUK Biobank participantsLIFE-Adult-StudyInherited genetic lociGenome-wide associationGanglion cell complex layerRetinal optical coherence tomography imagesRetinal nerve fiber layerAge-related macular degenerationBiobank participantsEye careNerve fiber layerOptical coherence tomography imagesIncident mortalityMacular OCT imagesLIFE-AdultIndependent associationsAssociation studiesSystemic healthGenetic associationGenome-wide analysis