2022
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry
McHenry A, Iyer K, Wang J, Liu C, Harigopal M. Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry. Expert Review Of Molecular Diagnostics 2022, 22: 559-574. PMID: 35658709, DOI: 10.1080/14737159.2022.2085508.Peer-Reviewed Original Research
2018
Strong androgen receptor expression can aid in distinguishing GATA3+ metastases
Boto A, Harigopal M. Strong androgen receptor expression can aid in distinguishing GATA3+ metastases. Human Pathology 2018, 75: 63-70. PMID: 29408697, DOI: 10.1016/j.humpath.2018.01.024.Peer-Reviewed Original ResearchConceptsGATA3-positive tumorsAndrogen receptor expressionBreast originMetastatic settingUrothelial originAR expressionAR stainingAndrogen receptorReceptor expressionBreast cancerUnknown originBreast cancer tissue microarrayMarker of breastStrong AR expressionCancer tissue microarrayMammaglobin expressionUrothelial carcinomaLobular carcinomaProgesterone receptorEstrogen receptorTissue microarrayMammary originCarcinomaGATA3 expressionGATA3
2012
Increasing Cytotechnologist Workload Above 100 Slides per Day Using the BD FocalPoint GS Imaging System Negatively Affects Screening Performance
Levi AW, Galullo P, Gordy K, Mikolaiski N, Schofield K, Elsheikh TM, Harigopal M, Chhieng DC. Increasing Cytotechnologist Workload Above 100 Slides per Day Using the BD FocalPoint GS Imaging System Negatively Affects Screening Performance. American Journal Of Clinical Pathology 2012, 138: 811-815. PMID: 23161714, DOI: 10.1309/ajcptydd9g2ncumf.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellCytodiagnosisDiagnostic ImagingFalse Negative ReactionsFemaleHumansImage Processing, Computer-AssistedMass ScreeningMedical Laboratory PersonnelQuality ControlSensitivity and SpecificityTime FactorsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsWorkloadComparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests
Levi AW, Beckman D, Hui P, Schofield K, Harigopal M, Chhieng DC. Comparing Two Methods of Detection for Chlamydia trachomatis in Liquid-Based Papanicolaou Tests. American Journal Of Clinical Pathology 2012, 138: 236-240. PMID: 22904135, DOI: 10.1309/ajcp2b7xqtcnamjp.Peer-Reviewed Original ResearchConceptsHC2 assayBD Viper SystemXTR TechnologyPositive predictive valueDNA assaysLiquid-based Papanicolaou testsNucleic acidsC trachomatisChlamydia trachomatisPredictive valueHybrid Capture 2Reverse transcriptase-polymerase chain reactionChlamydia trachomatis testingTranscriptase-polymerase chain reactionViper SystemComparable specificityCapture 2Papanicolaou testChlamydial infectionCytology samplesMethod of detectionThinPrep specimensTrachomatisAssaysSensitivity rate
2011
Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsHR-HPV testingHPV testingCIN 2Colposcopy rateHR-HPVRelative light units/cutoffCervical intraepithelial neoplasia 2High-risk human papillomavirusHR-HPV statusRLU/COIntraepithelial neoplasia 2Hybrid Capture 2Squamous intraepithelial lesionsCIN 1 lesionsLarge teaching hospitalNegative predictive valueLSIL cytologyHPV statusIntraepithelial lesionsCapture 2Human papillomavirusTeaching hospitalCytologic diagnosisSevere lesions
2009
Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy
Brandsma JL, Sun Y, Lizardi PM, Tuck DP, Zelterman D, Haines GK, Martel M, Harigopal M, Schofield K, Neapolitano M. Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 2009, 389: 100-107. PMID: 19443004, PMCID: PMC2918277, DOI: 10.1016/j.virol.2009.03.029.Peer-Reviewed Original ResearchConceptsRoutine cervical cancer screeningCervical cellsCervical cancer screeningHigh-grade lesionsLow-grade lesionsHPV16-positive samplesCervical progressionNegative cytologyCervical lesionsCancer screeningCervical samplesPathologic diagnosisCervical carcinogenesisClinical significanceHuman papillomavirus gene expressionLow-level methylationLarger studyE6 geneL1 regionLesionsAbnormal patternsClinical samplesPattern ADistinct methylation patternsHigh-level methylation
2007
Bimodal Population or Pathologist Artifact?
Rimm DL, Giltnane JM, Moeder C, Harigopal M, Chung GG, Camp RL, Burtness B. Bimodal Population or Pathologist Artifact? Journal Of Clinical Oncology 2007, 25: 2487-2488. PMID: 17557963, DOI: 10.1200/jco.2006.07.7537.Peer-Reviewed Original Research