2023
Multi-institutional Assessment of Pathologist Scoring HER2 Immunohistochemistry
Robbins C, Fernandez A, Han G, Wong S, Harigopal M, Podoll M, Singh K, Ly A, Kuba M, Wen H, Sanders M, Brock J, Wei S, Fadare O, Hanley K, Jorns J, Snir O, Yoon E, Rabe K, Soong T, Reisenbichler E, Rimm D. Multi-institutional Assessment of Pathologist Scoring HER2 Immunohistochemistry. Modern Pathology 2023, 36: 100032. PMID: 36788069, PMCID: PMC10278086, DOI: 10.1016/j.modpat.2022.100032.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBreast NeoplasmsFemaleGenes, erbB-2HumansImmunohistochemistryIn Situ Hybridization, FluorescencePathologistsReceptor, ErbB-2Reproducibility of ResultsConceptsOverall percent agreementHuman epidermal growth factor 2HER2 IHCReal-world settingEpidermal growth factor 2HER2-negative statusBreast cancer biopsiesCompanion diagnostic testsMulti-institutional assessmentGrowth factor 2Breast cancerImmunohistochemistry assaysCancer biopsiesHER2 immunohistochemistryPathologist concordanceIHCClinical standardsPercent agreementDiagnostic testsSubstantial discordanceERBB2 geneInterrater reliabilityPathologistsFactor 2Concordance
2022
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry
McHenry A, Iyer K, Wang J, Liu C, Harigopal M. Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry. Expert Review Of Molecular Diagnostics 2022, 22: 559-574. PMID: 35658709, DOI: 10.1080/14737159.2022.2085508.Peer-Reviewed Original ResearchConcordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists.
Mantrala S, Ginter PS, Mitkari A, Joshi S, Prabhala H, Ramachandra V, Kini L, Idress R, D'Alfonso TM, Fineberg S, Jaffer S, Sattar AK, Chagpar AB, Wilson P, Singh K, Harigopal M, Koka D. Concordance in Breast Cancer Grading by Artificial Intelligence on Whole Slide Images Compares With a Multi-Institutional Cohort of Breast Pathologists. Archives Of Pathology & Laboratory Medicine 2022, 146: 1369-1377. PMID: 35271701, DOI: 10.5858/arpa.2021-0299-oa.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceBreast NeoplasmsFemaleHumansObserver VariationPathologistsReproducibility of ResultsConceptsWhole slide imagingArtificial intelligenceNottingham grading systemDigital whole slide imagingVirtual microscopyBreast cancer gradingWhole slide imagesDeep learningAI methodologiesExplainable methodsDigital pathologySlide imagesCancer gradingMulti-institutional groupIntelligenceLearningImagesImportant criteriaFrameworkAdvent
2020
Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy
Ginter PS, Idress R, D’Alfonso T, Fineberg S, Jaffer S, Sattar AK, Chagpar A, Wilson P, Harigopal M. Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy. Modern Pathology 2020, 34: 701-709. PMID: 33077923, PMCID: PMC7987728, DOI: 10.1038/s41379-020-00698-2.Peer-Reviewed Original Research
2019
Interobserver variability in breast carcinoma grading results in prognostic stage differences
Rabe K, Snir OL, Bossuyt V, Harigopal M, Celli R, Reisenbichler ES. Interobserver variability in breast carcinoma grading results in prognostic stage differences. Human Pathology 2019, 94: 51-57. PMID: 31655171, DOI: 10.1016/j.humpath.2019.09.006.Peer-Reviewed Original ResearchConceptsPathologic prognostic stagePrognostic stageStage II carcinomaInterobserver variabilityIntra-observer variabilityGood intra-observer variabilityStage IABreast pathologistsConsecutive casesTumor gradeBreast carcinomaTumor gradingDiscordant gradesAJCC cancerDiscordant casesCarcinoma gradeInterobserver agreementGrading criteriaPathologistsCarcinomaComplete concordanceGradeOverall gradeGrading results
2016
Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement
Zarrella ER, Coulter M, Welsh AW, Carvajal DE, Schalper KA, Harigopal M, Rimm D, Neumeister V. Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement. Laboratory Investigation 2016, 96: 1016-1025. PMID: 27348626, PMCID: PMC5008858, DOI: 10.1038/labinvest.2016.73.Peer-Reviewed Original Research
2007
Bimodal Population or Pathologist Artifact?
Rimm DL, Giltnane JM, Moeder C, Harigopal M, Chung GG, Camp RL, Burtness B. Bimodal Population or Pathologist Artifact? Journal Of Clinical Oncology 2007, 25: 2487-2488. PMID: 17557963, DOI: 10.1200/jco.2006.07.7537.Peer-Reviewed Original Research
2004
Comparison of human papillomavirus DNA prevalence in atypical squamous cells of undetermined significance subcategories as defined by the original Bethesda 1991 and the new Bethesda 2001 Systems.
Pirog EC, Erroll M, Harigopal M, Centeno BA. Comparison of human papillomavirus DNA prevalence in atypical squamous cells of undetermined significance subcategories as defined by the original Bethesda 1991 and the new Bethesda 2001 Systems. Archives Of Pathology & Laboratory Medicine 2004, 128: 527-32. PMID: 15086283, DOI: 10.5858/2004-128-527-cohpdp.Peer-Reviewed Original ResearchConceptsAtypical squamous cellsHigh-grade squamous intraepithelial lesionsTBS 2001Squamous intraepithelial lesionsSquamous cellsASCUS casesIntraepithelial lesionsIndividual morphologic featuresMorphologic featuresHPV DNAHPV detectionPap testAtypical cellsUndetermined significanceBroad-spectrum HPV DNA amplificationControl groupHuman papillomavirus (HPV) DNA prevalenceASC-H casesBethesda 2001 systemPrevalence of HPVThinPrep Pap testsHPV DNA amplificationHuman papillomavirus DNAPanel of pathologistsBethesda System 2001
2003
Interpretative problems and preparative technique influence reliability of intraoperative parathyroid touch imprints.
Yao DX, Hoda SA, Yin DY, Kuhel WI, Harigopal M, Resetkova E, DeLellis RA. Interpretative problems and preparative technique influence reliability of intraoperative parathyroid touch imprints. Archives Of Pathology & Laboratory Medicine 2003, 127: 64-7. PMID: 12521369, DOI: 10.5858/2003-127-64-ipapti.Peer-Reviewed Original ResearchMeSH KeywordsCytodiagnosisFrozen SectionsHumansIntraoperative PeriodParathyroid DiseasesParathyroid GlandsReproducibility of ResultsRetrospective StudiesThyroid GlandConceptsFrozen section examinationParathyroid tissueIntraoperative consultationSection examinationUnanimous diagnosisLymph node casesSmall uniform cellsLymph nodesRetrospective studyThyroid surgeryHemorrhagic backgroundCytologic featuresPepper chromatinTissue 1Touch imprintsOval nucleiDiff-QuikNaked nucleiPT cellsThyroid casesFollicular arrangementConsultationDiagnosisExaminationPT cases