2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2020
Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients
Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation 2020, 21: 1304-1311. PMID: 33043603, PMCID: PMC7675520, DOI: 10.1111/ajt.16357.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsClinical implicationsCycle threshold valuesSOT patientsTransplant recipientsSymptom onsetYale New Haven Health SystemUpper respiratory tract samplesSARS-CoV-2 viral RNASARS-CoV-2 viral dynamicsAdult SOT recipientsRetrospective chart reviewRespiratory tract samplesSARS-CoV-2 cycle threshold valuesInfection prevention measuresCOVID-19 severityViral RNAHigher clinical acuityPrimary diagnostic testRT-PCR assaysSOT recipientsChart reviewViral loadAdmission severityNanima
Juthani-Mehta M. Nanima. New England Journal Of Medicine 2020, 384: 1488-1489. PMID: 33108099, DOI: 10.1056/nejmp2028693.Peer-Reviewed Original Research
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: 1611-1615. PMID: 31506700, DOI: 10.1093/cid/ciz021.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntibiotic-sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not ready for primetime
Datta R, Juthani-Mehta M. Antibiotic-sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not ready for primetime. Clinical Microbiology And Infection 2019, 25: 922-924. PMID: 31035018, PMCID: PMC6612576, DOI: 10.1016/j.cmi.2019.04.022.Commentaries, Editorials and LettersClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: e83-e110. PMID: 30895288, DOI: 10.1093/cid/ciy1121.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2015
Changing Clinicians’ Behavior: To Order or Not to Order a Urine Culture
Juthani-Mehta M. Changing Clinicians’ Behavior: To Order or Not to Order a Urine Culture. JAMA Internal Medicine 2015, 175: 1127-1129. PMID: 26011381, DOI: 10.1001/jamainternmed.2015.1888.Peer-Reviewed Original ResearchAntibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo
Madden GR, Argraves SM, Van Ness PH, Juthani-Mehta M. Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo. Infection Control And Hospital Epidemiology 2015, 36: 356-357. PMID: 25695180, PMCID: PMC4336946, DOI: 10.1017/ice.2014.66.Peer-Reviewed Original Research
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinseTests for Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Datunashvili A, Tinetti M. Tests for Urinary Tract Infection in Nursing Home Residents. JAMA 2014, 312: 1687-1688. PMID: 25335152, DOI: 10.1001/jama.2014.13554.Peer-Reviewed Original ResearchUrinary Tract Infections in Older Women
Mody L, Juthani-Mehta M. Urinary Tract Infections in Older Women. JAMA 2014, 311: 874-874. PMID: 24570259, PMCID: PMC4237003, DOI: 10.1001/jama.2014.1152.Peer-Reviewed Original ResearchUrinary Tract Infections in Older Women: A Clinical Review
Mody L, Juthani-Mehta M. Urinary Tract Infections in Older Women: A Clinical Review. JAMA 2014, 311: 844-854. PMID: 24570248, PMCID: PMC4194886, DOI: 10.1001/jama.2014.303.Peer-Reviewed Original ResearchConceptsSymptomatic urinary tract infectionRecurrent urinary tract infectionsUrinary tract infectionAsymptomatic bacteriuriaOlder womenTract infectionsUrine cultureRecurrent symptomatic urinary tract infectionsDiagnosis of UTIOlder community-dwelling womenEnglish-language human studiesChronic suppressive antibioticsCostovertebral angle painNegative dipstick resultsSymptomatic UTI episodesVaginal estrogen therapyAdverse effect profilePositive urine cultureLocal resistance ratesCommunity-dwelling womenLow pretest probabilityCareful clinical evaluationClinical diagnostic criteriaSearch of OvidRecent sexual intercourse
2013
Should antibiotic prophylaxis after urinary catheter removal be standard practice?
Juthani-Mehta M. Should antibiotic prophylaxis after urinary catheter removal be standard practice? The BMJ 2013, 346: f3938. PMID: 23794157, DOI: 10.1136/bmj.f3938.Peer-Reviewed Original ResearchModifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2012
Pilot Randomized Controlled Dosing Study of Cranberry Capsules for Reduction of Bacteriuria Plus Pyuria in Female Nursing Home Residents
Bianco L, Perrelli E, Towle V, Van Ness P, Juthani‐Mehta M. Pilot Randomized Controlled Dosing Study of Cranberry Capsules for Reduction of Bacteriuria Plus Pyuria in Female Nursing Home Residents. Journal Of The American Geriatrics Society 2012, 60: 1180-1181. PMID: 22690994, PMCID: PMC3375874, DOI: 10.1111/j.1532-5415.2012.03976.x.Peer-Reviewed Original Research
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original Research
2010
FEASIBILITY OF CRANBERRY CAPSULE ADMINISTRATION AND CLEAN‐CATCH URINE COLLECTION IN LONG‐TERM CARE RESIDENTS
Juthani‐Mehta M, Perley L, Chen S, Dziura J, Gupta K. FEASIBILITY OF CRANBERRY CAPSULE ADMINISTRATION AND CLEAN‐CATCH URINE COLLECTION IN LONG‐TERM CARE RESIDENTS. Journal Of The American Geriatrics Society 2010, 58: 2028-2030. PMID: 20929476, PMCID: PMC2953731, DOI: 10.1111/j.1532-5415.2010.03080.x.Peer-Reviewed Original Research