2021
International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease
Gordon I, Bettenworth D, Bokemeyer A, Srivastava A, Rosty C, de Hertogh G, Robert M, Valasek M, Mao R, Li J, Harpaz N, Borralho P, Pai R, Odze R, Feakins R, Parker C, Guizzetti L, Nguyen T, Shackelton L, Sandborn W, Jairath V, Baker M, Bruining D, Fletcher J, Feagan B, Pai R, Rieder F. International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease. Gut 2021, 71: 479-486. PMID: 33952604, PMCID: PMC8903083, DOI: 10.1136/gutjnl-2021-324374.Peer-Reviewed Original ResearchConceptsSmall bowel stricturesMucosal inflammatory diseasesBowel stricturesCrohn's diseaseHistopathological scoring systemScoring systemInflammatory diseasesIncreased bowel wall thicknessCrypt architectural distortionIntact surface epitheliumSurgically resected specimensPyloric gland metaplasiaSmall bowel Crohn's diseaseEffective medical therapyLos Angeles methodologyPaneth cell hyperplasiaBowel wall thicknessBasal lymphoplasmacytosisAnastomotic strictureMedical therapyStricture diseaseCell hyperplasiaClinical trial efficiencyNeutrophilic inflammationLymphoid aggregates
2004
Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis
Robert M, Tang L, Hao L, Reyes-Mugica M. Patterns of Inflammation in Mucosal Biopsies of Ulcerative Colitis. The American Journal Of Surgical Pathology 2004, 28: 183-189. PMID: 15043307, DOI: 10.1097/00000478-200402000-00005.Peer-Reviewed Original ResearchConceptsColonic mucosal biopsiesCrypt architectural distortionYears of ageEpithelial injuryMucosal biopsiesUlcerative colitisHistological featuresArchitectural distortionRectal biopsyCrypt abscessesPresentation of ulcerative colitisYears of follow-upInitiation of therapyPlasma cell infiltrationDiagnosis of ulcerative colitisPattern of inflammationDegree of colitisDegree of inflammationAge groupsDiagnosed ulcerative colitisPathological confirmationInitial presentationCrypt branchingNo significant differenceHistological criteria