2021
Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis
Zhang B, Lapenta K, Wang Q, Nam JH, Chung D, Robert ME, Nathanson MH, Yang X. Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. Journal Of Biological Chemistry 2021, 297: 100887. PMID: 34146542, PMCID: PMC8267550, DOI: 10.1016/j.jbc.2021.100887.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsTrefoil factor 2Liver injuryStellate cellsActivation of HSCsPrimary hepatic stellate cellsPlatelet-derived growth factor receptor betaChronic liver diseaseGrowth factor receptor betaProcess of fibrogenesisLiver-specific deletionFactor 2Spontaneous fibrosisLiver diseaseLiver fibrosisFibrogenic processReceptor betaFibrogenesisWT hepatocytesProtein expressionFibrosisHepatocytesInjuryNovel factorActivation
1994
Intragraft cytokine and cytotoxic T lymphocyte (CTL) specific protein expression as predictors of rat small intestine transplant rejection.
McDiarmid S, Farmer D, Kuniyoshi J, Robert M, Khadavi A, Shaked A, Busuttil R. Intragraft cytokine and cytotoxic T lymphocyte (CTL) specific protein expression as predictors of rat small intestine transplant rejection. Transplantation Proceedings 1994, 26: 1520-1. PMID: 8030018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCytokinesGraft RejectionInterferon-gammaInterleukin-2Interleukin-6Intestine, SmallMembrane GlycoproteinsPerforinPolymerase Chain ReactionPore Forming Cytotoxic ProteinsRatsRats, Inbred BNRats, Inbred LewReceptors, Interleukin-2RNA, MessengerSerine EndopeptidasesT-Lymphocytes, CytotoxicTime FactorsTransplantation, HomologousTransplantation, IsogeneicTumor Necrosis Factor-alphaConceptsIntragraft cytokinesTransplant rejectionSpecific protein expressionProtein expressionCytokines