2021
Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis
Zhang B, Lapenta K, Wang Q, Nam JH, Chung D, Robert ME, Nathanson MH, Yang X. Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis. Journal Of Biological Chemistry 2021, 297: 100887. PMID: 34146542, PMCID: PMC8267550, DOI: 10.1016/j.jbc.2021.100887.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon TetrachlorideCell LineCells, CulturedExocytosisHepatic Stellate CellsHepatocytesHumansLiver CirrhosisMiceN-AcetylglucosaminyltransferasesNecroptosisSignal TransductionTrefoil Factor-2ConceptsHepatic stellate cellsTrefoil factor 2Liver injuryStellate cellsActivation of HSCsPrimary hepatic stellate cellsPlatelet-derived growth factor receptor betaChronic liver diseaseGrowth factor receptor betaProcess of fibrogenesisLiver-specific deletionFactor 2Spontaneous fibrosisLiver diseaseLiver fibrosisFibrogenic processReceptor betaFibrogenesisWT hepatocytesProtein expressionFibrosisHepatocytesInjuryNovel factorActivation
2020
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance
Yang Y, Li X, Luan HH, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, Wang Q, Robert ME, Perry RJ, Chung D, Shulman GI, Yang X. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 16616-16625. PMID: 32601203, PMCID: PMC7368321, DOI: 10.1073/pnas.1916121117.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosamineAdipose TissueAnimalsHumansMacrophage ActivationMacrophagesMiceMice, KnockoutN-AcetylglucosaminyltransferasesObesityPhosphorylationRibosomal Protein S6 Kinases, 90-kDaSignal TransductionConceptsRibosomal protein S6 kinase beta-1Macrophage proinflammatory activationGlcNAc signalingProinflammatory activationUnexpected roleWhole-body metabolismNutrient fluxesLipid accumulationImmune cell activationGlcNAcHomeostatic mechanismsMetabolic disturbancesBeta 1Cell activationDiet-induced metabolic dysfunctionDiet-induced obese miceActivationWhole-body insulin resistanceMacrophage inflammationGlcNAcylationOGTPeripheral tissuesPhosphorylationEnhanced inflammationInsulin resistance
2019
O-GlcNAc transferase suppresses necroptosis and liver fibrosis
Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. O-GlcNAc transferase suppresses necroptosis and liver fibrosis. JCI Insight 2019, 4: e127709. PMID: 31672932, PMCID: PMC6948774, DOI: 10.1172/jci.insight.127709.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHumansLiver CirrhosisMaleMiceMice, KnockoutN-AcetylglucosaminyltransferasesNecroptosisConceptsReceptor-interacting protein kinase 3Liver fibrosisLiver diseaseHepatocyte necroptosisEthanol-induced liver injuryAlcoholic liver cirrhosisChronic liver diseaseMultiple liver diseasesWeeks of ageProtein expression levelsPortal inflammationLiver cirrhosisLiver injuryBallooning degenerationElevated protein expression levelsSpontaneous genetic modelFibrosisKey suppressorKey mediatorMiceProtein kinase 3CirrhosisExpression levelsGlcNAc levelsMixed lineage kinase