1997
Na+‐dependent and ‐independent Cl−/HCO exchange mediate cellular HCO transport in cultured human intrahepatic bile duct cells
Strazzabosco M, Joplin R, Zsembery A, Wallace L, Spirli C, Fabris L, Granato A, Rossanese A, Poci C, Neuberger J, Okolicsanyi L, Crepaldi G. Na+‐dependent and ‐independent Cl−/HCO exchange mediate cellular HCO transport in cultured human intrahepatic bile duct cells. Hepatology 1997, 25: 976-985. PMID: 9096607, DOI: 10.1002/hep.510250431.Peer-Reviewed Original ResearchConceptsEpithelial membrane antigenIntracellular acid loadHuman cholangiocytesAcid loadIntrahepatic bile duct cellsFactor VIII-related antigenIntracellular cyclic adenosine monophosphate (cAMP) concentrationsBiliary HCO3- secretionPediatric liver transplantationAdministration of agentsCyclic adenosine monophosphate concentrationsHuman hepatocyte growth factorVIII-related antigenBile duct cellsNormal liver tissueBiliary epithelial cellsCl- channel inhibitorsHepatocyte growth factorAdenosine monophosphate concentrationsIntracellular cAMP concentrationLiver transplantationReduced graftAbsence of HCO3Biliary treeAcid loader
1995
Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor‐α, and insulinlike growth factor‐II on Na+/H+ exchange activity
Strazzabosco M, Poci C, Spirlì C, Zsembery A, Granato A, Massimino M, Crepaldi G. Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor‐α, and insulinlike growth factor‐II on Na+/H+ exchange activity. Hepatology 1995, 22: 588-597. PMID: 7635429, DOI: 10.1002/hep.1840220232.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmilorideAmmonium ChlorideAnimalsCarcinoma, HepatocellularCarrier ProteinsCattleCell DivisionDNAEpidermal Growth FactorFetal BloodFluoresceinsFluorescent DyesHumansHydrogen-Ion ConcentrationInsulin-Like Growth Factor IILiver NeoplasmsSodium-Bicarbonate SymportersSodium-Hydrogen ExchangersTransforming Growth Factor alphaTumor Cells, CulturedConceptsInsulinlike growth factor IIEpidermal growth factorTGF-alphaGrowth factor IIHep G2 cellsGrowth factorFactor IIG2 cellsAdministration of EGFLiver growth factorCl/HCO3 exchangeExtrahepatic tumorsAcid/base homeostasisHepatic tumorsAcid loaderFetal calf serumAcid extrudersHepatoma cell linePresence of FCSAcid loadExchange activityMetabolic activationHCO3- exchangeProliferative stimulusAmilorideIntracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor-α, and insulinlike growth factor-II on Na+H+ exchange activity
Strazzabosco M, Poci C, Spirlì C, Zsembery A, Granato A, Massimino M, Crepaldi G. Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor-α, and insulinlike growth factor-II on Na+H+ exchange activity. Hepatology 1995, 22: 588-597. DOI: 10.1016/0270-9139(95)90584-7.Peer-Reviewed Original ResearchInsulinlike growth factor IIEpidermal growth factorGrowth factor IIHep G2 cellsGrowth factorFactor IIG2 cellsAdministration of EGFLiver growth factorCl/HCO3 exchangeExtrahepatic tumorsAcid/base homeostasisHepatic tumorsAcid loaderFetal calf serumAcid extrudersHepatoma cell linePresence of FCSAcid loadExchange activityMetabolic activationHCO3- exchangeProliferative stimulusTGFαAmiloride