2018
Animal models of cholangiocarcinoma: What they teach us about the human disease
Cadamuro M, Brivio S, Stecca T, Kaffe E, Mariotti V, Milani C, Fiorotto R, Spirli C, Strazzabosco M, Fabris L. Animal models of cholangiocarcinoma: What they teach us about the human disease. Clinics And Research In Hepatology And Gastroenterology 2018, 42: 403-415. PMID: 29753731, DOI: 10.1016/j.clinre.2018.04.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnimal modelsNovel therapeutic approachesRelevant animal modelsPathogenesis of cholangiocarcinomaBiliary carcinogenesisTreatment optionsTherapeutic approachesRodent modelsLethal cancersClinical phenotypeExperimental modelCholangiocarcinomaAggressive behaviorCell interactionsHuman diseasesComplex cell biologyMultiple cell interactionsMolecular perturbationsPathogenesisTumorsCancerDiseaseCarcinogenesis
2017
Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness
Brivio S, Cadamuro M, Strazzabosco M, Fabris L. Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness. World Journal Of Hepatology 2017, 9: 455-468. PMID: 28396716, PMCID: PMC5368623, DOI: 10.4254/wjh.v9.i9.455.Peer-Reviewed Original ResearchTumor reactive stromaReactive stromaCCA progressionStromal cellsAggressive epithelial malignancyReactive stromal cellsProgression of cholangiocarcinomaEarly lymphDismal prognosisBiliary carcinogenesisCancer cell behaviorConventional chemotherapyBreast carcinomaDesmoplastic microenvironmentEpithelial malignanciesCancer aggressivenessCell aggressivenessNeoplastic cellsCholangiocarcinomaMetastatic disseminationCombinatorial therapySoluble factorsCancer typesParacrine communicationExtracellular matrix