2018
Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation
Riva G, Cilibrasi C, Bazzoni R, Cadamuro M, Negroni C, Butta V, Strazzabosco M, Dalprà L, Lavitrano M, Bentivegna A. Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation. Genes 2018, 9: 522. PMID: 30373123, PMCID: PMC6267016, DOI: 10.3390/genes9110522.Peer-Reviewed Original ResearchGSC proliferationMethylation changesBioinformatics analysisGenome-wide dataStem cellsWnt/β-catenin signalingCell-signaling pathwaysWnt/β-catenin signaling activationWnt/β-cateninValproic acidΒ-catenin signalingVPA effectsHistone deacetylase inhibitorsGlioma stem cellsTrypan blue assayReal-time PCRLuciferase reporterN-cadherinSignaling ActivationPleiotropic effectsAnti-cancer effectsΒ-cateninE-cadherinCommon malignant brain tumorGSC invasion
2017
Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway
Cilibrasi C, Riva G, Romano G, Cadamuro M, Bazzoni R, Butta V, Paoletta L, Dalprà L, Strazzabosco M, Lavitrano M, Giovannoni R, Bentivegna A. Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway. PLOS ONE 2017, 12: e0169854. PMID: 28081224, PMCID: PMC5231344, DOI: 10.1371/journal.pone.0169854.Peer-Reviewed Original ResearchConceptsGlioma stem cellsGlioblastoma multiformeResveratrol exposureSolid tumorsPleiotropic health benefitsProtein levelsHigh recurrence rateMalignant brain tumorsBetter therapeutic strategiesCell proliferationEpithelial-mesenchymal transition (EMT) programGrade IV astrocytomaGSC linesInteresting therapeutic approachWnt Signaling PathwayMedian survivalRecurrence rateGlioma stem cell proliferationCurrent therapiesPathway-related genesPolyphenolic phytoalexinGBM patientsTherapeutic approachesTherapeutic strategiesBrain tumors