2013
Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice
Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M. Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. Journal Of Hepatology 2013, 59: 124-130. PMID: 23500150, PMCID: PMC3777645, DOI: 10.1016/j.jhep.2013.02.025.Peer-Reviewed Original ResearchMeSH Keywords1-NaphthylisothiocyanateAmyloid Precursor Protein SecretasesAnimalsBile Ducts, IntrahepaticCalcium-Binding ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLiver RegenerationMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMorphogenesisPyridinesReceptor, Notch2RNA, Small InterferingSerrate-Jagged ProteinsSignal TransductionStem CellsConceptsWild-type miceHepatic progenitor cellsBiliary damageType miceProgenitor cellsDuctular reactionΓ-secretase inhibitor treatmentTubule formationNotch signalingNotch-2 receptorRBP-JkBiliary repairMature ductsLiver-specific defectCKO miceInhibitor treatmentAbstractTextMiceNotch inhibitionNotch-1Jagged-1Notch-2ANITAIMSSOX-9
2010
Foxa1 and Foxa2 regulate bile duct development in mice
Strazzabosco M. Foxa1 and Foxa2 regulate bile duct development in mice. Journal Of Hepatology 2010, 52: 765-767. PMID: 20347503, PMCID: PMC2862815, DOI: 10.1016/j.jhep.2009.12.022.Peer-Reviewed Original ResearchIL-6 expressionBile duct developmentClinical investigationDuct developmentGlucocorticoid receptorBile duct expansionForkhead box protein A1American SocietyIL-6 promoterIL-6 transcriptionBiliary treeBile duct formationCholangiocyte proliferationConditional gene ablationGene ablationDevelopmental competenceLiverAdult liverDuct expansionEmbryonic liverProtein A1Liver specificationFOXA1MiceLate phase