1998
Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines
Zsembery Á, Spirlì C, Granato A, LaRusso N, Okolicsanyi L, Crepaldi G, Strazzabosco M. Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines. Hepatology 1998, 28: 914-920. PMID: 9755225, DOI: 10.1002/hep.510280403.Peer-Reviewed Original ResearchConceptsCholangiocyte cell lineNHE activityPurinergic agonistsBiliary epithelial cell lineExtracellular ATPCell linesIntracellular cyclic adenosine monophosphate (cAMP) concentrationsBiliary HCO3- secretionRat cholangiocyte cell lineCyclic adenosine monophosphate concentrationsAdenosine receptor agonistsBiliary epithelial cellsMz-ChA-1 cellsAdenosine monophosphate concentrationsSynergistic stimulatory effectApical administrationEpithelial cell lineReceptor agonistP2Y2 receptorPurinergic receptorsBile volumePharmacological profileApical Cl- channelsBasolateral administrationHCO3- secretion
1991
Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH
Benedetti A, Strazzabosco M, Corasanti J, Haddad P, Graf J, Boyer J. Cl(-)-HCO3- exchanger in isolated rat hepatocytes: role in regulation of intracellular pH. American Journal Of Physiology 1991, 261: g512-g522. PMID: 1887897, DOI: 10.1152/ajpgi.1991.261.3.g512.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmmoniaAnimalsBariumBicarbonatesCarrier ProteinsCells, CulturedChloride-Bicarbonate AntiportersChloridesHydrogen-Ion ConcentrationIntracellular FluidKineticsLiverMaleRatsRats, Inbred StrainsConceptsAlkaline loadPH-sensitive dye BCECFMM H2DIDSPHi recoveryRegulation of intracellularRat hepatocyte monolayersAcid extrudersMM DIDSRat hepatocytesElectrophysiological techniquesDye BCECFHCO3- exchangerIsolated rat hepatocytesConstant pHoIntracellularMembrane potentialHepatocyte monolayersHepatocytesAcid loadingEffect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers
Strazzabosco M, Sakisaka S, Hayakawa T, Boyer J. Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. American Journal Of Physiology 1991, 260: g58-g69. PMID: 1987808, DOI: 10.1152/ajpgi.1991.260.1.g58.Peer-Reviewed Original ResearchConceptsBiliary HCO3- concentrationUrsodeoxycholic acidRat hepatocyte coupletsBiliary pHAcid loadEffect of UDCABile duct lumenHepatocyte coupletsIsolated rat hepatocyte coupletsBiliary epitheliumHCO3- concentrationDuct lumenRemoval of ClHCO3- exchangeRat liverLiverIPRLHepatocytesHypercholeresisPerfusateBileExcretionEpitheliumAmiloride
1985
Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses.
Okolicsanyi L, Venuti M, Strazzabosco M, Biral A, Orlando R, Iemmolo R, Nassuato G, Muraca M, Padrini G, Miglioli P. Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses. International Journal Of Clinical Pharmacology And Therapeutics 1985, 23: 434-8. PMID: 4044077.Peer-Reviewed Original Research
1984
Oral and intravenous pharmacokinetics of ranitidine in patients with liver cirrhosis.
Okolicsanyi L, Venuti M, Strazzabosco M, Orlando R, Nassuato G, Iemmolo R, Lirussi F, Muraca M, Pastorino A, Castelli G. Oral and intravenous pharmacokinetics of ranitidine in patients with liver cirrhosis. International Journal Of Clinical Pharmacology And Therapeutics 1984, 22: 329-32. PMID: 6086536.Peer-Reviewed Original ResearchConceptsCompensated liver cirrhosisLiver cirrhosisPharmacokinetics of ranitidineCirrhotic patientsUrinary recoveryUnchanged drugHealthy controlsPlasma concentrationsIntravenous pharmacokineticsPharmacokinetic dataPatientsCirrhosisOral bioavailabilityRanitidinePharmacokineticsHigh-performance liquid chromatographyPerformance liquid chromatographyCirrhoticsLiquid chromatographyControlThe pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis.
Okolicsányi L, Venuti M, Strazzabosco M, Iemmolo R, Nassuato G, Orlando R, Lirussi F. The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis. Physiology International 1984, 64: 393-400. PMID: 6099684.Peer-Reviewed Original ResearchConceptsCompensated liver cirrhosisLiver cirrhosisPlasma concentrationsUrinary recoveryOral administrationDoses of cimetidinePharmacokinetics of cimetidineHigher plasma concentrationsSame plasma concentrationIntravenous cimetidineCirrhotic patientsSingle dosesH2 receptorsOral routeNormal subjectsPharmacokinetic parametersAdministration routeCimetidineRanitidineCirrhosisPharmacokineticsDosesPatientsAdministration