2015
Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection
Esaki H, Ewald DA, Ungar B, Rozenblit M, Zheng X, Xu H, Estrada YD, Peng X, Mitsui H, Litman T, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection. Journal Of Allergy And Clinical Immunology 2015, 135: 153-163. PMID: 25567045, PMCID: PMC4452382, DOI: 10.1016/j.jaci.2014.10.037.Peer-Reviewed Original ResearchConceptsNonlesional AD skinLaser capture microdissectionAD transcriptomeNormal skinAD skinNonlesional skinNovel ImmuneCapture microdissectionAtopic dermatitis lesionsBarrier genesPossible cellular sourcesAtopic dermatitisHealthy volunteersEpidermal alterationsBarrier phenotypeCellular sourceImmune moleculesCellular subsetsDermatitis lesionsImmuneDermal compartmentSkinGenomic profilesPatientsMolecular signatures
2014
Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology
Khattri S, Shemer A, Rozenblit M, Dhingra N, Czarnowicki T, Finney R, Gilleaudeau P, Sullivan-Whalen M, Zheng X, Xu H, Cardinale I, de Guzman Strong C, Gonzalez J, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology. Journal Of Allergy And Clinical Immunology 2014, 133: 1626-1634. PMID: 24786238, PMCID: PMC4122665, DOI: 10.1016/j.jaci.2014.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiomarkersCluster AnalysisCyclosporineDendritic CellsDermatitis, AtopicEpidermisFemaleGene Expression ProfilingGene Expression RegulationHumansHyperplasiaImmunosuppressive AgentsInflammationMaleMiddle AgedPhenotypeSignal TransductionT-Lymphocyte SubsetsTreatment OutcomeYoung AdultConceptsClinical improvementAtopic dermatitisCytokine activationEpidermal alterationsAD skin lesionsEpidermal pathologyWeeks of treatmentT cell cytokinesCommon inflammatory diseaseSystemic immunosuppressantsSCORAD scoreNonlesional skinWeek 12Inflammatory pathwaysTissue inflammationBiopsy specimensInflammatory diseasesSignificant gene expression changesSevere diseaseEpidermal hyperplasiaImmunohistochemistry studiesSkin lesionsSpecific cytokinesWeek 2CsA effects