Comparative analysis of pseudogenes across three phyla
Sisu C, Pei B, Leng J, Frankish A, Zhang Y, Balasubramanian S, Harte R, Wang D, Rutenberg-Schoenberg M, Clark W, Diekhans M, Rozowsky J, Hubbard T, Harrow J, Gerstein MB. Comparative analysis of pseudogenes across three phyla. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 13361-13366. PMID: 25157146, PMCID: PMC4169933, DOI: 10.1073/pnas.1407293111.Peer-Reviewed Original ResearchConceptsGenome evolutionLarge effective population sizesNumerous duplication eventsProtein-coding genesNumber of pseudogenesEffective population sizePotential regulatory roleDuplication eventsSelective sweepsGene familyHuman pseudogenesPrimate lineageDifferent remodeling processesPseudogenesUpstream sequencesHigh deletion ratePromoter activityBiochemical activityRegulatory rolePopulation sizePartial activityGenomePhylaDeletion rateLineages