2018
Flipping ATP to AMPlify Kinase Functions
Sheetz JB, Lemmon MA. Flipping ATP to AMPlify Kinase Functions. Cell 2018, 175: 641-642. PMID: 30340038, PMCID: PMC6421561, DOI: 10.1016/j.cell.2018.10.011.Peer-Reviewed Original Research
2015
Ligand regulation of a constitutively dimeric EGF receptor
Freed DM, Alvarado D, Lemmon MA. Ligand regulation of a constitutively dimeric EGF receptor. Nature Communications 2015, 6: 7380. PMID: 26060020, PMCID: PMC4465127, DOI: 10.1038/ncomms8380.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorLin-3Ligand-induced receptor dimerizationInsulin receptor family membersReceptor family membersLET-23Minor structural rearrangementsDomain compositionLigand regulationGrowth factor receptorDimerization armAllosteric changesExtracellular regionOligomerization stateReceptor dimerizationMutational analysisEGF receptorFactor receptorStructural rearrangementsKey eventsCovalent dimersStructural studiesFamily membersCaenorhabditisDimers
2009
ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor
Alvarado D, Klein DE, Lemmon MA. ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature 2009, 461: 287-291. PMID: 19718021, PMCID: PMC2762480, DOI: 10.1038/nature08297.Peer-Reviewed Original Research
2008
Functional selectivity of EGF family peptide growth factors: Implications for cancer
Wilson KJ, Gilmore JL, Foley J, Lemmon MA, Riese DJ. Functional selectivity of EGF family peptide growth factors: Implications for cancer. Pharmacology & Therapeutics 2008, 122: 1-8. PMID: 19135477, PMCID: PMC2665203, DOI: 10.1016/j.pharmthera.2008.11.008.Peer-Reviewed Original ResearchConceptsEGF family membersPeptide growth factorsFunctional selectivityGrowth factorErbB family receptorsFamily membersNeck cancerReceptor couplingReceptor tyrosine phosphorylationMalignant phenotypeDivergent biological responsesSame receptorFamily receptorsEGF familyReceptorsErbB receptorsG proteinsCancerCancer chemotherapeuticsCell culturesLigand activityTyrosine phosphorylationColorectalSubsequent differencesBiological responsesHarnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment
Lemmon M. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. 2008 DOI: 10.21236/ada488172.Peer-Reviewed Original ResearchEGF receptor family membersEGF receptor signalingEGF-like ligandsReceptor family membersNew structural informationFruit flyYeast surface displayEGF receptorEGFR ligandsSecreted inhibitorsProtein scaffoldsReceptor signalingFunctional fragmentsSurface displayHuman EGFProtein therapeuticsTherapeutic designGrowth factorStructural informationNew therapeuticsExperimental approachStructure determinationFamily membersDrosophilaReceptorsMechanism of Activation and Inhibition of the HER4/ErbB4 Kinase
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase. Structure 2008, 16: 460-467. PMID: 18334220, PMCID: PMC2858219, DOI: 10.1016/j.str.2007.12.016.Peer-Reviewed Original ResearchConceptsErbB4 kinaseEGF receptorBa/F3 cellsReceptor tyrosine kinasesMechanism of activationHER4/ErbB4ErbB family membersKinase domainHER2/ErbB2Kinase activationMutagenesis studiesTyrosine kinaseF3 cellsKinaseDimer conformationErbB familyNormal developmentInactive formAsymmetric dimerMammary glandErbB4ActivationFamily members
2007
Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment
Lemmon M. Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment. 2007 DOI: 10.21236/ada471085.Peer-Reviewed Original ResearchEGF receptor family membersEGF receptor signalingEGF-like ligandsReceptor family membersNew structural informationFruit flyYeast surface displayEGF receptorSecreted inhibitorsEGFR ligandsProtein scaffoldsReceptor signalingFunctional fragmentsSurface displayHuman EGFProtein therapeuticsTherapeutic designGrowth factorNew therapeuticsStructural informationExperimental approachStructure determinationFamily membersDrosophilaReceptors