2008
Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase. Structure 2008, 16: 460-467. PMID: 18334220, PMCID: PMC2858219, DOI: 10.1016/j.str.2007.12.016.Peer-Reviewed Original ResearchConceptsErbB4 kinaseEGF receptorBa/F3 cellsReceptor tyrosine kinasesMechanism of activationHER4/ErbB4ErbB family membersKinase domainHER2/ErbB2Kinase activationMutagenesis studiesTyrosine kinaseF3 cellsKinaseDimer conformationErbB familyNormal developmentInactive formAsymmetric dimerMammary glandErbB4ActivationFamily members
2002
Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization
Yu J, Lemmon M. Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization. 2002 DOI: 10.21236/ada409630.Peer-Reviewed Original ResearchB cell linesErbB2 interactsBreast cancer therapyAbsence of IL2B cell proliferationIL2 receptor betaBreast cancerReceptor betaERBB2 overexpressionErbB receptor ligandsReceptor ligandsErbB2Cancer therapyValuable targetVivo systemGamma chainIntracellular domainMechanism of activationExtracellular domain