2016
Posttranslational modification of islet autoantigens in type 1 diabetes
Yang M, Wen L, Herold K, Mamula M. Posttranslational modification of islet autoantigens in type 1 diabetes. The Journal Of Immunology 2016, 196: 118.9-118.9. DOI: 10.4049/jimmunol.196.supp.118.9.Peer-Reviewed Original ResearchAnti-insulin autoimmunityType 1 diabetesNon-obese diabetic (NOD) micePrediabetic NOD miceDevelopment of T1D.Onset of hyperglycemiaHuman pancreatic isletsNOD miceHuman T1DHuman T1D.Islet autoantigensImmune toleranceAutoimmune responseDiabetic miceAutoimmune diseasesInflammatory cytokinesTissue pathologyPancreatic isletsAutoantibodiesT1D.Islet proteinsAutoantigensOxidative stressInsulin biosynthesisAutoimmunity
2008
Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL Ipr/lpr antibodies
JAMES J, MAMULA M, HARLEY J. Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL Ipr/lpr antibodies. Clinical & Experimental Immunology 2008, 98: 419-426. PMID: 7527740, PMCID: PMC1534503, DOI: 10.1111/j.1365-2249.1994.tb05507.x.Peer-Reviewed Original ResearchConceptsMRL-lpr/lpr miceLpr/lpr miceAutoimmune serologySLE patientsLpr micePatient seraEpitope 5Systemic lupus erythematosus (SLE) patient seraEpstein-Barr nuclear antigen 1Lupus patients' seraNuclear antigen 1Precipitin-positive seraHuman lupus autoantibodiesNormal human serumMajor antigenic regionSm DPositive patientsAutoimmune responseSm autoantigenLupus autoantibodiesNormal controlsPatientsEpitope 4Mouse serumAntigen 1Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus
Yang M, Mamula M. Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus. The FASEB Journal 2008, 22: 668.20-668.20. DOI: 10.1096/fasebj.22.1_supplement.668.20.Peer-Reviewed Original ResearchLupus-inducing drugsDrug-induced lupusT cell hyperproliferationMRL miceCell hyperproliferationOnset of autoantibodiesLupus-prone miceProtein L-isoaspartyl methyltransferaseT cell functionDose-dependent mannerERK 1/2 pathwayAutoimmune responseMultiple sclerosisRheumatoid arthritisLymphocyte functionMurine modelSelf proteinsLupusCell functionMiceDrugsHydralazineIntracellular levelsSpontaneous eventsHyperproliferation
2006
Increase in intracellular protein modification associated with altered lymphocyte functions in autoimmunity
Yang M, Doyle H, Gee R, Aswad D, Mamula M. Increase in intracellular protein modification associated with altered lymphocyte functions in autoimmunity. The FASEB Journal 2006, 20: a964-a964. DOI: 10.1096/fasebj.20.5.a964-a.Peer-Reviewed Original ResearchT cellsT-cell proliferative defectsLupus-like autoimmunityT cell hyperproliferationAutoimmune miceImmune toleranceAutoimmune responseLupus CD4Peripheral circulationLymphocyte functionAntigen stimulationT lymphocytesThymic selectionB cellsBone marrowCell hyperproliferationHyperproliferative responseAutoimmunityLymphocytesMiceProliferative defectPhysiologic pHNon-enzymatic modificationIsoaspartyl proteinsVivo
2001
Post-translational protein modifications in antigen recognition and autoimmunity
Doyle H, Mamula M. Post-translational protein modifications in antigen recognition and autoimmunity. Trends In Immunology 2001, 22: 443-449. PMID: 11473834, DOI: 10.1016/s1471-4906(01)01976-7.Peer-Reviewed Original Research
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityB-LymphocytesBinding, CompetitiveCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1997
B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya
ROTH R, GEE R, MAMULA M. B Lymphocytes as Autoantigen‐presenting Cells in the Amplification of Autoimmunitya. Annals Of The New York Academy Of Sciences 1997, 815: 88-100. PMID: 9186642, DOI: 10.1111/j.1749-6632.1997.tb52047.x.Peer-Reviewed Original ResearchConceptsB cell-deficient miceCell-deficient miceNaive T cellsT cellsSelf antigensIL-4IL-5B cellsB7-2 costimulatory moleculesAutoantigen-presenting cellsAutoreactive T cellsT cell toleranceAntigen-presenting cellsCytokine mRNA responsesB cell subsetsNaive lymphAutoimmune responseCell subsetsCostimulatory moleculesAntigen presentationCytokine mRNAIFN-gammaB lymphocytesCell toleranceMRNA response
1989
Human monoclonal anti-La antibodies. The La protein resides on a subset of Ro particles.
Mamula M, Silverman E, Laxer R, Bentur L, Isacovics B, Hardin J. Human monoclonal anti-La antibodies. The La protein resides on a subset of Ro particles. The Journal Of Immunology 1989, 143: 2923-8. PMID: 2478628, DOI: 10.4049/jimmunol.143.9.2923.Peer-Reviewed Original Research