2021
Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis
Szymczak F, Colli M, Mamula M, Evans-Molina C, Eizirik D. Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Science Advances 2021, 7: eabd7600. PMID: 33523973, PMCID: PMC7787485, DOI: 10.1126/sciadv.abd7600.Peer-Reviewed Original ResearchConceptsType 1 diabetesLupus erythematosusTarget tissuesRheumatoid arthritisMultiple sclerosisAutoimmune diseasesImmune systemSystemic lupus erythematosusTarget tissue levelRepurposing of drugsDisease-specific signaturesGene expression signaturesImmune assaultSimilar molecular signaturesClinical useTissue levelsDiseaseHigh expressionExpression signaturesDifferent diseasesErythematosusArthritisSclerosisDiabetesTherapy
2013
Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152)
Yang M, Connolly S, Wen L, Herold K, Mamula M. Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152). The Journal Of Immunology 2013, 190: 172.3-172.3. DOI: 10.4049/jimmunol.190.supp.172.3.Peer-Reviewed Original ResearchNOD miceType 1 diabetesDiabetes-prone NOD miceEarly-onset diabetic patientsPre-diabetic NOD miceDiabetic NOD miceT cell autoimmunityPathogenesis of T1DPancreatic islet proteinsCell autoimmunityDiabetic patientsImmune toleranceRheumatoid arthritisMultiple sclerosisAutoimmune diseasesMurine modelTarget organsTherapeutic targetSelf proteinsPancreatic isletsIslet proteinsMiceOxidative stressPeripheral erythrocytesDiabetes
2008
Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus
Yang M, Mamula M. Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus. The FASEB Journal 2008, 22: 668.20-668.20. DOI: 10.1096/fasebj.22.1_supplement.668.20.Peer-Reviewed Original ResearchLupus-inducing drugsDrug-induced lupusT cell hyperproliferationMRL miceCell hyperproliferationOnset of autoantibodiesLupus-prone miceProtein L-isoaspartyl methyltransferaseT cell functionDose-dependent mannerERK 1/2 pathwayAutoimmune responseMultiple sclerosisRheumatoid arthritisLymphocyte functionMurine modelSelf proteinsLupusCell functionMiceDrugsHydralazineIntracellular levelsSpontaneous eventsHyperproliferation