2017
Oxidative Modifications in Tissue Pathology and Autoimmune Disease
Yang ML, Doyle H, Clarke SG, Herold K, Mamula M. Oxidative Modifications in Tissue Pathology and Autoimmune Disease. Antioxidants & Redox Signaling 2017, 29: 1415-1431. PMID: 29088923, PMCID: PMC6166690, DOI: 10.1089/ars.2017.7382.Peer-Reviewed Original ResearchConceptsPost-translational protein modificationReactive oxygen speciesProtein modificationGene expressionAberrant gene expressionInitiation of apoptosisChromosome inactivationOxidative stressDNA methylationCellular pathwaysGenetic elementsLevels of tissueMicroenvironmental influencesProtein expressionOxygen speciesOxidative modificationTissue pathogenesisPathwayExpressionTherapeutic manipulationPotential therapeutic manipulationEnvironmental influencesCellsIntracellular autoantigensSilencing
2016
Posttranslational modification of islet autoantigens in type 1 diabetes
Yang M, Wen L, Herold K, Mamula M. Posttranslational modification of islet autoantigens in type 1 diabetes. The Journal Of Immunology 2016, 196: 118.9-118.9. DOI: 10.4049/jimmunol.196.supp.118.9.Peer-Reviewed Original ResearchAnti-insulin autoimmunityType 1 diabetesNon-obese diabetic (NOD) micePrediabetic NOD miceDevelopment of T1D.Onset of hyperglycemiaHuman pancreatic isletsNOD miceHuman T1DHuman T1D.Islet autoantigensImmune toleranceAutoimmune responseDiabetic miceAutoimmune diseasesInflammatory cytokinesTissue pathologyPancreatic isletsAutoantibodiesT1D.Islet proteinsAutoantigensOxidative stressInsulin biosynthesisAutoimmunity
2013
Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152)
Yang M, Connolly S, Wen L, Herold K, Mamula M. Identification of posttranslational modified autoantigens in Type 1 diabetes. (P4152). The Journal Of Immunology 2013, 190: 172.3-172.3. DOI: 10.4049/jimmunol.190.supp.172.3.Peer-Reviewed Original ResearchNOD miceType 1 diabetesDiabetes-prone NOD miceEarly-onset diabetic patientsPre-diabetic NOD miceDiabetic NOD miceT cell autoimmunityPathogenesis of T1DPancreatic islet proteinsCell autoimmunityDiabetic patientsImmune toleranceRheumatoid arthritisMultiple sclerosisAutoimmune diseasesMurine modelTarget organsTherapeutic targetSelf proteinsPancreatic isletsIslet proteinsMiceOxidative stressPeripheral erythrocytesDiabetes